Promotor: T.H. Oosterkamp

Detecting nanoscopic objects plays an important role in nanoscience in particular, in the rapidly growing field of nanobiology. The forebear to modern super-resolution microscopy for single molecule investigation, is fluorescence microscopy.

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

The investigations described in this thesis lay out strategies aimed at advancing antibiotic research and development. The examples presented revolve around two main approaches: understanding drug-target interactions and target identification.

Autophagy is a fundamental degradative process, maintaining cellular homeostasis and functions in host defense against intracellular pathogens, including mycobacteria and Salmonella.

Promotor: A. Kros

The aim of this thesis was to develop novel treatment strategies for different types of eye melanoma utilizing zebrafish models. We first establish orthotopic and ectopic xenograft models for uveal and conjunctival melanoma by engraftment of the immortalized cells derived from these tumors into zebrafish…

In this thesis, we have studied the potential of the zebrafish larval model in studying the ECS, as a complementary model to the existing rodent models.

Principles of Environmental Sciences provides a comprehensive picture of the principles, concepts and methods that are applicable to problems originating from the interaction between the living and non-living environment and mankind. Both the analysis of such problems and the way solutions to environmental…

Of all the mass in our Universe, 80% is thought to consist of a hypothetical and invisible substance called dark matter (DM).

The aim of this thesis is to develop and study a robust and adaptable scaffold for supramolecular polymer self-assembly in water.

Pseudomonas Aeruginosa is a Gram-negative bacterium which can form biofilms, increasing its resistance against antibiotics and the host immune system. Polysaccharides are an integral part of this biofilm, one of these polysaccharides is called Psl. PslG is a glycosidase, able to cleave this polysaccharide,…

Source: Structure , Volume 22, Issue 8, pp. 1120-1139 (2014)

De zoektocht naar nieuwe antibiotica vergemakkelijken. Gilles van Wezel, hoogleraar moleculaire biotechnologie bij het Instituut Biologie Leiden (IBL), wil dit doen door te kijken naar overeenkomsten in het DNA van antibiotica-producerende bacteriën. Van Wezel heeft voor dit onderzoeksproject een ERC…

De

Promotie

In de Nederlandse natuur verdwijnen plantensoorten die afhankelijk zijn van bestuiving door insecten. Milieuwetenschapper Kaixuan Pan toont dat aan na analyse van 87 jaar aan metingen van meer dan 365.000 locaties. Verschillende media in binnen- en buitenland berichtten over de studieresultaten. Hieronder…

Promotie

Promotie

Bacteriën leven tijdelijk zonder hun celwand als er voor hen gevaarlijke virussen in de buurt zijn. Opmerkelijk, want de celwand vormt een stevige barrière tegen dreigingen van buitenaf. Toch is de vondst goed te verklaren én kan het een gevolg hebben voor het bestrijden van ziekteverwekkende bacteriën,…

De vier Leidse promovendi Loes Janssen, Mirjam Wever, Dianne van der Heide en Lisanne van Houtum werken mee aan onderzoek om depressieve jongeren te helpen met een betere diagnostiek. Doe je mee? Ook ouders van jongeren zonder psychische klachten zijn welkom.

In this dissertation, the synthesis and characterization of a series of iron complexes based on different ligand platforms are described.

The mission of our group is understanding how science communication works to improve the interaction between science and society. We believe better science communication can improve our society and engage many different groups with science, also improving science.

Promotor: Prof.dr. M. Ubbink

Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.

Dark matter is one of the biggest mysteries of the Universe. Its properties cannot be explained with the known laws of physics and elementary particles.

Heart failure is a major health care problem with high mortality.

The plant hormone auxin regulates plant growth and development through polar cell-to-cell transport-generated maxima and minima. PIN FORMED (PIN) auxin efflux carriers determine the direction of this auxin flow through their asymmetric placement on the plasma membrane (PM).

In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.

Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar-Jagalska

In the search for sustainable energy solutions, the idea of artificial photosynthesis has been proposed as an approach with which to use water and sunlight to produce hydrogen.

Binnen Quantum Leiden doen verschillende groepen onderzoek naar quantumnetwerken en quantumsensing.

Atoms and molecules are the basic units of matter. If we keep dividing a bar of gold or a glass of water into smaller parts, at the end we are left with a single gold atom or a water molecule.

Promotor: Prof.dr. D. Bouwmeester, Co-Promotor: M.J.A. de Dood

In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).

Promotor: Prof.dr. H.J.A. Rottgering

Humans and songbirds learn their vocalizations early in life by exposure to the vocalizations of adult conspecifics. Often, better learning outcomes are achieved with live, social, tutors than with audio-only exposure to vocalizations.

Anthropogenic noise has been shown to affect marine animals in various ways, this may have fitness consequences at individual and population level. This thesis aims to increase insight into the quantification of sound-induced behavioural responses that are relevant to fitness, and into factors that…

Promotores: A.H. Meijer, H.P. Spaink

Promotor: Prof.dr. E. Bouwman, Co-Promotor: S. Bonnet

Leiden University College The Hague (LUC) biedt een 3-jarige bacheloropleiding aan waarin je je focust op Global Challenges; grote uitdagingen waar de mensheid mee te maken heeft: Vrede & Rechtvaardigheid, Diversiteit, Duurzaamheid en Welvaart. Je hebt ruimte om de opleiding zo in te richten als je…

Electrons in a crystal lattice have properties that may differ from those of a free electron in vacuum.

Promotor: Prof.dr. J.W.M. Frenken

Promotor: S.M. Verduyn Lunel

Als een nieuwe methode is ontwikkeld om een (neuro-)psychologische aandoening of hieraan gerelateerde gedragsfactoren te herkennen en te behandelen, kan deze nog niet direct in de klinische praktijk worden ingezet. Eerst moet de methode geëvalueerd worden, bij voorkeur in gerandomiseerde, gecontroleerde…

The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…

Leiden University and the Ministry of Infrastructure and Water Management are involved in a collaboration in the form of a research project titled 'Data-Driven Risk Assessment in Infrastructure Networks'

This thesis addresses the chemical processes that determine the compositions of giant planet atmospheres.

As a non-invasive genetic method, eDNA based approaches have become an important component of ecologists' and environmental managers' toolkits for biomonitoring in conservation and an increasingly important source of ecological knowledge.