In summary, the collective results described in this thesis show that nanoparticulate vaccines can be delivered intradermally by coated and hollow microneedles and evoke antigen-specific immune responses.

Promotor: Prof.dr. E. Eliel, Co-Promotor: M.J.A. de Dood

Promotor: P.D. Grünwald

This thesis discusses several questions regarding the double ramification cycle as a Chow class on the moduli space of stable n-pointed genus g curves using tools from so-called logarithmic geometry.

Promotor: P.G.L. Klinkhamer, Co-Promotores: K. Vrieling, P.P.J. Mulder

Kunst en vrije tijd, Kunst en vrije tijd

Promotor: W.T. de Groot

This thesis explored the molecular pharmacological mechanisms of targeting CB2R via investigation of novel drug discovery concepts such as target binding kinetics, allosteric modulation and biased signaling.

Promotor: Prof.dr. W.J.G.M. Peijnenburg

Promotor: M.T.M. Koper, Co-Promotor: L.B.F. Juurlink

Fungal infections pose a significant threat to individuals with compromised immune systems and despite advancements in diagnosis and treatment, they continue to jeopardize patient’s health.

Galaxies in the local Universe fall into two main categories of spirals and ellipticals. In this Thesis, we explore the structural evolution of galaxies into this bimodal distribution.

Mechanical metamaterials are carefully engineered materials whose properties are controlled by their structure, not by their composition, which allows using metamaterials to study and control physical effects in detail⁠.

The Institute of Environmental Sciences has carried out and participates in several projects that deal with the analysis of energy systems.

In this work, we attempt to answer the question:

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We present an extensive study of methods for exactly solving stochastic constraint (optimisation) problems (SCPs) in network analysis. These problems are prevalent in science, governance and industry.

Promotor: R. Cramer

Identification of the products or product groups that have the greatest environmental impact from a life-cycle perspective using environmentally extended input-output analysis.

Promotor: F.P. Israel, Co-Promoter: R. Meijerink

A remarkable population of short period transiting rocky exoplanets with equilibrium temperatures on the order of 2,000 K has recently been discovered.

Promotor: Prof.dr. P. Stevenhagen, Co-promotor: B. de Smit

Over the past years it has been discovered that the population of extra-solar planets is large and diverse.

This work is dedicated to interpreting in cohomological terms the special values of zeta functions of arithmetic schemes.

HEPGAME is a research project that combines the world’s fastest computer algebra system for High Energy Physics equations, FORM, with insights from artificial intelligence. The name combines High Energy Physics and Games.

International trade has played a major role in defining the modern global economy. Trade, however, entangles the environmental pressures of economic sectors, giving the illusion of environmental improvements, while the opposite may be occurring.

Promotor: Prof.dr. C.W.J. Beenakker

In previous studies at our laboratory it was demonstrated that drug exposure of HepG2 cells can lead to an altered TNFα-induced NF-κB oscillatory phenotype, concurrent with a synergistically increased sensitivity for TNFα-induced apoptosis.

Given the accelerating appearance of antimicrobial resistance, there is an urgent need for more fundamental research into novel antibiotic strategies. The work in this thesis helps to address this global problem by developing new antibiotic compounds, inspired by the antibacterial mechanisms of the…

Planets are formed in disks of gas and dust around young stars.

Global healthcare is on the verge of an antibiotic availability crisis as bacteria have evolved resistance to nearly all known antibacterials. Identifying new antibiotics that operate via novel modes-of-action is therefore of high priority.

Uncertainty and noise are frequently-encountered obstacles in real-world applications of numerical optimization. The practice of optimization that deals with uncertainties and noise is commonly referred to as robust optimization.

Promotores: Prof.dr. G. Miley & Prof.dr. J.M. van den Broek

Dissolving microneedles are a subgroup of microneedle types that completely dissolve within the skin. During this dissolving process the vaccine, stored in the needle matrix, is released into the skin.

Streptomyces bacteria are a valuable source of natural products, many of which are used in the clinic or in biotechnology.

Promotor: Prof.dr. J.N. Kok, Co-Promotor: W.A. Kosters

Several single-stranded RNA viruses make use of Xrn1-resistant RNAs in their 3’ untranslated regions of their genome RNAs in order to increase their pathogenicity.

Errors are everywhere, and mechanical failures are especially common: buckled grain silos and cracked support columns are, justly, seen as an issue to be avoided.

Every organisms in the tree of life faces the same challenge: the length of its DNA exceeds the volume of the cell it needs to fit in. Several strategies have evolved to solve this problem, one of them being the expression of proteins that bind and organize the DNA.

Three major cosmology-focused missions are planned for the next decade: the Euclid space telescope, the Vera C. Rubin Observatory in Chile, and the Nancy Grace Roman Space Telescope.

Promotor: Prof.dr. P. Stevenhagen

Promotores: J. Jonkers, K.E. de Visser

Galaxy intrinsic alignments induce a major astrophysical contamination to weak gravitational lensing measurements and need to be modelled and mitigated when extracting cosmological information from such measurements.

Promotor: H.W. Lenstra

CMLCA is a software tool that supports the technical steps of the Life Cycle Assessment. The focus of the program is on advanced computational aspects of life cycle inventory calculations.

Cardiovascular syndromes are the major cause of death in Western societies.

Promotores: B. van de Water; P. Hogendoorn; J. Bovée Co-Promotor: E.H.J. Danen

The type-IV secretion system (T4SS) is a machinery able to transfer DNA and proteins between bacteria and in certain cases also to eukaryotic cells.

Promotor: P. J. J. Hooykaas, Co-promotor: R. Offringa

This thesis applies data mining in commercial settings in the telecommunications industry.