1,240 zoekresultaten voor “room were in roos environmental” in de Publieke website
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Layered loyalties: the Natuurkundige Commissie in the Netherlands Indies (1820-1850)
This dissertation, Layered Loyalties: The Natuurkundige Commissie in the Netherlands Indies (1820-1850), studies the Natuurkundige Commissie.
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Insights into the mechanism of electrocatalytic CO2 reduction and concomitant catalyst degradation pathways
This work describes several studies into the electroreduction of carbon dioxide (CO2RR), both regarding mechanistical aspects and catalyst stability considerations. Mechanistic insights into carbon-carbon bond formation on a silver catalyst are described in Ch 2, were we find an acetaldehyde-like surface…
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Terpenoids and terpenoid indole alkaloids in Catharanthus roseus cell suspension cultures
Promotor: Prof.dr. R. Verpoorte, Co-Promotores: N.R. Mustafa, A.E. Schulte
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Ruthenium-peptide conjugates for targeted phototherapy
As leading cause of death worldwide, cancer is responsible for nearly 10 million deaths in 2020 according to World Health Organization (WHO). Cisplatin and its derivatives are commonly used chemotherapy agents for current cancer treatment in the clinics.
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The Miliuseae revisited: phylogenetic, taxonomic, and palynological studies in a major clade of Annonaceae
Promotor: Prof.dr. E.F. Smets, Co-Promotor: L.W. Chatrou
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Microneedle-mediated vaccine delivery
Promotores: Prof.dr. J. A. Bouwstra, Prof.dr. W. Jiskoot
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The advantages and disadvantages of bioorthogonal proteins
This thesis describes the use of bioorthogonal proteins in immunological settings. It provides an introduction towards the field of protein modification, which was used throughout the thesis for the expression of proteins containing unnatural amino acids.
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The flux and flow of data: connecting large datasets with machine learning in a drug discovery envirionment
This thesis focuses on data found in the field of computational drug discovery. New insight can be obtained by applying machine learning in various ways and in a variety of domains. Two studies delved into the application of proteochemometrics (PCM), a machine learning technique that can be used to…
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Systematic investigations into the role of ceramide subclass composition on lipid organization and skin barrier
The lipids in the uppermost layer of the skin, the stratum corneum (SC), play an important role in the skin barrier function. The three main SC lipid classes are ceramides (CER), cholesterol and free fatty acids.
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Artificial metallo-proteins for photocatalytic water splitting: stability and activity in artificial photosynthesis
Climate change is one of the largest challenges faced by humanity. To combat this research into alternatives to fossil fuels is ongoing. Dihydrogen is considered a good alternative fuel, since its burning only forms water.
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Discovery of selective diacylglycerol lipase β inhibitors
Diacylglycerol lipases (DAGLα and DAGLβ) are responsible for the biosynthesis of the endocannabinoid 2-arachidonoylglycerol (2-AG) in the brain and peripheral tissues. Selective DAGLβ inhibitors have been proposed as a potential treatment for inflammatory diseases with reduced potential for central…
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The power of biotic ligand models : site-specific impact of metals on aquatic communities
Promotor: G.R. de Snoo, Co-promotores: M.G. Vijver, J.P.M. Vink
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Crossing boundaries
Celebrating 20 years of environmental research in Cagayan Valley and Sierra Madre
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Erfgoed tegen klimaatverandering: ‘Het kan helpen om het bewustzijn te vergroten’
In veel grote steden kan klimaatverandering tot een watercrisis leiden. Een goede omgang met erfgoed kan dit tegengaan, betoogt Fokke Gerritsen. De directeur van het Nederlands instituut in Turkije (NIT) gebruikte seed money van het Impact Support Netwerk om dit aan de hand van een Istanbuls aquaduct…
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BioSustain
Examining the sustainability aspects of biotechnology, especially those related to the production of ethanol from biomass.
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IDREEM - Increasing industrial resource efficiency in European mariculture
What are the environmental trade-offs for SMEs considering moving from monoculture aquaculture practice towards IMTA? What are the environmental trade-offs comparing IMTA species with their conventional monoculture alternatives?
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A macro level assessment of material circularity
A sustainable resource management is an essential aspect to satisfy the current human needs without compromising the needs of future generations.
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The Weight of Nations
Material outflows from industrial economies.
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Aquatic eDNA: Beyond Species Presence
As a non-invasive genetic method, eDNA based approaches have become an important component of ecologists' and environmental managers' toolkits for biomonitoring in conservation and an increasingly important source of ecological knowledge.
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Towards a Sustainable and Circular Metals Economy
In-use stocks of products can be considered as intermediaries between human needs and the physical world.
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Voetafdrukfamilie geeft completer beeld milieuschade
Het wemelt van de voetafdrukken die de druk van de mens op het milieu berekenen. Milieukundige Kai Fang is de eerste die een voetafdrukfamilie ontwikkelde waardoor milieuschade en uitputting van hulpbronnen beter gemeten kan worden. Promotie 24 november.
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PhD position in 'Effects of Pollution at the Ecosystem Level'
Wiskunde en Natuurwetenschappen, Centrum voor Milieuwetenschappen Leiden (CML)
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Papyrus, rozen en een zeekat: de Leidse Dioskurides
Lezing, Studium Generale
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All-gender toilet Academiegebouw
Academiegebouw, Rapenburg 73, 2311 GJ, Leiden
- BiodiverCity: stadse natuur voor stadse mensen
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Herta Mohrgebouw (gerealiseerd)
In maart 2024 werd het Herta Mohrgebouw (voorheen: Cluster Zuid) bouwkundig opgeleverd. Het is het derde project in de ontwikkeling van de Humanities Campus. Met de vernieuwing van de gebouwen zorgt de universiteit voor een duurzame Humanities Campus met moderne faciliteiten en een aantrekkelijke onderwijsomgeving…
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Student reviews of our courses
Read all about the experiences of our students who followed one of the Academic Language Center's (online) courses in the past semester.
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PhD candidate in Industrial Ecology
Wiskunde en Natuurwetenschappen, Centrum voor Milieuwetenschappen Leiden (CML)
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PhD candidate on soil fungal ecology
Wiskunde en Natuurwetenschappen, Centrum voor Milieuwetenschappen Leiden (CML)
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Oxford University Press versnelt goedkeuring WHO-regelgeving met medewerking van Ginevra Le Moli
The International Health Regulations are a set of binding rules which organise the global response to viral outbreaks and other similar transboundary risks to public health.
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Assembling anisotropic colloidal building blocks
This PhD-thesis presents a study on micron-sized particles, so-called colloids. By controlling the chemical and physical properties of these particles, such as the interparticle interaction and the particles’ shape, colloids can act as building blocks that self-assembly into larger structures.
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Discovery of Reversible Monoacylglycerol Lipase Inhibitors
Monoacylglycerol lipase (MAGL) is the principal enzyme responsible for hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-AG). MAGL inhibition provides several potential therapeutic opportunities, including anti-nociceptive, anti-inflammatory and anti-cancer activity.
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Using insertional mutagenesis to identify breast cancer drivers and therapy resistance genes in mice
In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.
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Fisheries in the Waza Logone Floodplain. An Analysis of the Status of the Fisheries Sector and Mitigation of Conflicts within the Sector in North
Promotores: Prof.dr. G.A. Persoon & Prof. dr. H.H. de Iongh
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Structural characterization of bacterial proteins involved in antibiotic resistance and peptidoglycan biosynthesis
This thesis describes the structural and biochemical characterization of the β-lactamase BlaC from Mycobacterium tuberculosis (Mtb), and the Alr and YlmE proteins from Streptomyces coelicolor A3(2).Mtb is the main cause of tuberculosis.
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Mass Spectrometry-Based Degradomics Analysis of Toxoid Vaccines
The chemical and structural heterogeneity of toxoid vaccines makes their analysis challenging. However, detailed insights on a molecular level can be obtained by mass spectrometry.
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The Interactions of Human Mobility and Farming Systems and Impacts on Biodiversity and Soil Quality in the Western Highlands of Cameroon
Promotors: Prof.dr. G.R. de Snoo, Prof.dr. G.A. Persoon, Prof.dr.ir. H.H. de Iongh
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X-ray spectroscopy of interstellar dust: from the laboratory to the Galaxy
In this thesis, we present new laboratory data of interstellar dust analogues.
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Targeted Therapy for Triple-Negative Breast Cancer
The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.
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Redox Interconversion between Metal Thiolate and Disulfide Compounds
In the last decade, the redox interconversion between metal thiolate and disulfide compounds has been extensively investigated for copper, but not for other transition metal ions.
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Species Literacy: The perception and cultural portrayal of animals
In his dissertation Michiel Hooykaas outlines the results of six empirical research projects focused at biodiversity awareness in the Netherlands, specifically people’s knowledge about animals.
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The early stress response of jasmonic acid in cell suspension cultures of Catharanthus roseus
In order to gain a better insight into the basis of the rapid jasmonic acid (JA)-mediated stress response, an integrated approach using a targeted high-resolution mass spectrometry-based (HRMS) platform, was conducted to monitor the metabolism of JA using the model system of cell suspension cultures…
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Targeting Human Proteasomes: Substrates, Inhibitors and Prodrugs
Large parts of the research described in this Thesis aims at the development of oligopeptide-masked toxins and their in situ immunoproteasome-mediated activation.
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Discovery of novel Antibiotics from Actinomycetes by Integrated Metabolomics & Genomics Approaches
Promotor: G.P. van Wezel, Co-promotor: Y.H. Choi
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Impact of plant domestication on spermosphere and rhizosphere microbiome composition
Microbiome composition of the spermosphere and the rhizosphere of wild and modern bean accessions grown in an agricultural and a native soil from Colombia was characterized by metagenomics and cultivation-dependent approaches.
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Multi-omics studies of the control of growth and antibiotic production of Streptomyces
Actinobacteria are Gram-positive bacteria that have a complex multicellular life cycle and are well known for their ability to produce a wide range of bioactive natural products (NPs).
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Unsprayed field margins: effects on environment, biodiversity and agricultural practice
A management strategy has been developed for field margins to reduce pesticide drift to non-target areas and to promote biodiversity on arable land. To this end, 3 and 6 m wide strips along the edges of winter wheat, sugar beet and potato crops have been left unsprayed with herbicides and insecticides…
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Quantitative systems pharmacology modeling of biotherapeutics in oncology
In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.
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The spin evolution of accreting and radio pulsars in binary systems
Pulsars were first discovered in 1967 and since then the population has grown and expanded over several wavelengths.
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Biodiesel production using blue-green cyanobacterium Synechococcus elongatus PCC 7942
Promotores: Prof.dr. C.A.M.J.J. van den Hondel, Prof.dr. V. Meyer (Technische Universität Berlin)