All life on earth contains DNA, which is used to store biological information. Organisms compact their DNA in order for it to fit inside their cell(s).

Lysosomal acid glucosylceramidase (GBA1) is a lysosomal enzyme that degrades glucolipids with its main substrate being glucosylceramide (GlcCer). Defects in the GBA1 gene lead to glycosphingolipidosis Gaucher disease (GD), in which the hydrolysis of GlcCer is impaired and therefore, it accumulates in…

Promotor: Roeland M.H. Merks

The research described in this thesis focused on the use of bioorthogonal antigens to investigate immunological processes in antigen presenting cells. Bioorthogonal antigens are antigenic proteins produced through recombinant expression in a methionine auxotrophic E. coli strain.

The type-IV secretion system (T4SS) is a machinery able to transfer DNA and proteins between bacteria and in certain cases also to eukaryotic cells.

The investigations described in this thesis lay out strategies aimed at advancing antibiotic research and development. The examples presented revolve around two main approaches: understanding drug-target interactions and target identification.

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

What would be the environmental performance of the Carbon4PUR technology at industrial scale in the future?

Image-Pro Plus, ImageJ, Cell Profiler, R, Knime en NIS-elements

Promotor: Thomas Hankemeier, Co-promotores: Heiko van der Linden, Paul Vulto

Het programma ‘uNMR-NL’, een project om een 1.2 GHz NMR spectrometer in Nederland te plaatsen voor chemisch onderzoek, heeft 18,5 miljoen euro ontvangen om deze grootschalige faciliteit op te zetten. Dit wordt vanmiddag in Utrecht bekend gemaakt door staatssecretaris Zijlstra van OCW en Jos Engelen,…

Afstudeerceremonie

Oratie

Nierfalen is een serieus probleem omdat nieren zichzelf niet kunnen regenereren na ernstige beschadiging. Een mogelijke oplossing bestaat uit het kunstmatig laten groeien van gezond nierweefsel. Daarvoor moeten wetenschappers eerst de ontwikkeling begrijpen tijdens de allereerste fase, in de foetus.…

Studievoorlichting

In the thesis we demonstrated an 85% state transfer efficiency between two mechanical modes coupled to a common optical mode via stimulated Raman adiabatic passage (STIRAP) in the classical regime. We also showed possibilities to manipulate quantum states of the mechanical modes via STIRAP.

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Anjali Pandit (Leids Instituut voor Chemisch onderzoek) heeft een FOM-projectruimte onderzoeksbeurs toegekend gekregen voor haar voorstel ‘Tuning into the photosynthetic membrane with atomistic precision’.

There is an increasing amount of attention on EU and its Member States contributions to implementation of two landmark agreements: the Paris Climate Agreement and the UN Agenda 2030 with Sustainable Development Goals (SDGs). Absent from the current literature is an analysis of the political effect of…

Solar energy is used by photosynthetic organisms to drive energy required cellular processes. Is absorbed by two groups of pigments, located in the LHCs.

The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.

Promotores: A.H. Meijer, H.P. Spaink

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

The applications of studying the early development of insects range from agriculture to material science.

In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…

This thesis describes the functional analysis of the Arabidopsis AHL15 gene.

Studievoorlichting

Promotor: R. Gill, Co-promotor: P. Massart

Promotor: Prof.dr. A. Doelman, Co-promotor: V. Rottschäfer

Met de NMR faciliteit doen we onderzoek naar de synthese van paramagnetische moleculen om kennis te vergaren over de structuur en dynamiek van eiwitten. Deze kennis kan dienen als basis voor een medicijn dat zich hecht aan een eiwit of voor de ontwikkeling van vaccins. Medicijnontwikkeling is één van…

Subproject of the ERC project 'Challenging the Liberal World Order from Within: The Invisible History of the United Nations and the Global South'.

eLaw onderzoekt de rol van het recht in de informatiemaatschappij: hoe kan het recht bijdragen aan een goede werking van informatie- en communicatietechnologie, en het gebruik ervan door burgers, bedrijven en overheden?

This thesis describes the development of a variety of mannosylated conjugates. Antigen presenting cells bear mannoside recognizing receptors that actively transport antigen into the cell. This thesis exploits this feature for the development of improved vaccines.

Promotor: H.S. Overkleeft, Co-Promotor: B.I. Florea

In this thesis the combinatorial use of bioorthogonal labelling and Electron Microscopy (EM)-based imaging techniques is explored to enable observations of specific molecular targets in their ultrastructural context within the cell.

Promotores: C.A.M.J.J. van den Hondel, V. Meyer, Co-promotor: A.F.J. Ram

Viral diseases constitute one of the major challenges in modern medicine. Membrane-targeting have broad-spectrum potential and could distinguish viral membranes from the host cell plasma membrane by the difference in membrane curvature.

Prof.dr.ir. Lucas van Vliet is per 1 september 2012 aangesteld als hoogleraar Meerdimensionale beeldanalyse bij de faculteit Wiskunde en Natuurwetenschappen. Van Vliet blijft als hoofdfunctie zijn gelijknamige leerstoel bij de TU Delft bezetten.

Promotor: H.J.M. de Groot

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