Promotor: C.A.J. Knibbe, Co-promotores: H.P.A. van Dongen, B. van Ramshorst

This thesis is comprised of three chapters covering the theme of studying semistable varieties by looking at their dual combinatorial objects.

Promotie

Promotie

In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).

Dit zijn de mensen die binnen de Universiteit Leiden actief zijn op het gebied van kunstmatige intelligentie.

The progressive loss and degeneration of dopaminergic neurons is a major pathological hallmark of Parkinson's disease (PD). The onset and progression of PD can be triggered by multiple risk factors, for instance, genetic mutation, environmental exposure, and aging.

The external tissues of plants and animals are colonized by microbial communities termed microbiota. When organisms are exposed to environmental pollutants, these substances will therefore encounter microbiota at the exposure interface.

Promotor: K.J. Batenburg

Promotor: J.N. Kok, Co-promotor: M.S. Lew

This thesis is largely an experimental study on the formation of solid-state simple and complex organic molecules in the H2O-rich and CO-rich ice phases of dense interstellar clouds and dark cores.

This thesis considers multi-prover commitment schemes whose security is based on restrictions on the communication between the provers.

Promotores: A.P. IJzerman, H.W.T. van Vlijmen

Glycosidases (GHs) are enzymes responsible for the degradation of carbohydrates and play many roles in human health and pathophysiology. Often, abnormal levels of glycosidase activity are markedly linked to human pathologies.

Complex Organic Molecules (COMs) have been detected in objects across different stages of stellar evolution.

Wil je een volledige academische opleiding? Dan ga je na je bachelor door met een masteropleiding. Met een masterdiploma op zak heb je meer kans op een baan op academisch niveau. Na afronding krijg je de titel Master of Arts (MA).

Promotor: Prof.dr. T. Hankemeier, Co-promotor: Theo Reijmers

This thesis studies the geometry of representation varieties and character stacks. These are spaces parametrizing the representations of a finitely generated group, typically the fundamental group of a compact manifold, into an algebraic group G.

In this thesis, we have studied the potential of the zebrafish larval model in studying the ECS, as a complementary model to the existing rodent models.

The ideas underlying this thesis are that lipidomics may improve the diagnosis of liver metabolic diseases, and can provide further insights into the underlying pathophysiology of these diseases.

Including modelling as part of software development appears to have various benefits.

Het merendeel van de wetenschappers, van archeologen tot zoölogen, verzamelt enorme hoeveelheden gegevens. Hun databanken bevatten grote hoeveelheden informatie die voor de mens moeilijk te filteren zijn. Met een stevige basis in de statistiek en de computerwetenschappen kunnen we algoritmes ontwikkelen…

The lipids in the uppermost layer of the skin, the stratum corneum (SC), play an important role in the skin barrier function. The three main SC lipid classes are ceramides (CER), cholesterol and free fatty acids.

In this thesis we study the landscape of gravitational models which modify GR by introducing an additional scalar degree of freedom (d.o.f.) to source Cosmic Acceleration.

Kunst en vrije tijd, Kunst en vrije tijd

The research in this dissertation aims to optimise blood donation processes in the framework of the Dutch national blood bank Sanquin. The primary health risk for blood donors is iron deficiency, which is evaluated based on donors' hemoglobin and ferritin levels.

Traditional drug discovery approaches have been hampered by (in vitro) cell-culture models that poorly represent the situation in the human body.

Promotores: W. Th. F. den Hollander, M.O. Heydenreich

Promotores: Prof.dr. M. Danhof, Prof.dr. D.R. Stanski

The overarching clinical aim of this thesis was to improve pharmacological pain management by characterizing the pharmacodynamics of analgesics. This promotion has been awarded the predicate cum laude.

Promotores: W.T. de Groot, M. Tchuenté, Co-promotor: J.P. Cheylan

Het ontwikkelen, gebruiken en evalueren van groepsopdrachten in het hoger onderwijs.

In this thesis, I study 1) metabolic alterations in tuberculosis related to wasting syndrome in human patients as well as in rodent and fish animal models. 2) effects of the mutation of the leptin gene on cachexia and diabetes in rodent and zebrafish animal models.

GLOBOX is a spatially differentiated multimedia fate, exposure and effect model. It is used for the calculation of spatially differentiated LCA characterisation factors on a global scale.

Promotores: Prof.dr. J.N. Kok, Prof.dr. M.R.V. Chaudron (Chalmers Univ., Sweden)

Promotor: W. T. F. den Hollander, F. H. J. Redig

Promotor: Ed F. Deprettere, Co-promotor: Todor P. Stefanov

Low-carbon (LE) technologies have a significant potential to reduce the total carbon emissions in China.

Hydrodesulfurization (HDS) is an ubiquitous part of oil refining that ensures that fuels are cleaned of impurities and environment release of pollutants such as SOx and NOx gasses are minimized.