In this thesis, we show how MRFM can usefully contribute to the field of condensed-matter.

This thesis explored the molecular pharmacological mechanisms of targeting CB2R via investigation of novel drug discovery concepts such as target binding kinetics, allosteric modulation and biased signaling.

In this thesis, two potential therapeutic targets for diabetic nephropathy were dentified and investigated. First, we show that glomerular clusterin is upregulated in diabetic nephropathy and demonstrated that recombinant clusterin protein can protect the podocytes against oxidative stress in vitro.…

In een longitudinale studie onderzochten Adva Eichengreen en collega's hoe aspecten van emotionele intelligentie de ontwikkeling van de geestelijke gezondheid van adolescenten beïnvloeden. Zo identificeerden ze potentiële waarschuwingssignalen en doelen voor interventieprogramma's.

Promotor: I. A. G. Snellen, Co-promotor: M. A. Kenworthy

Drug-induced liver injury (DILI) is one of the main reasons for drug attrition during pre-clinical and clinical phases of drug development as well as for drug withdrawal post-marketing.

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman

Model based approaches, integrating physiological parameters or linking exposure with response, are powerful tools to quantify and evaluate the impact of genetic differences that are reflected as variability of drug exposure and/or clinical response(s). This thesis “Pharmacogenomics in Drug Development: …

With the help of quantum mechanics, digital quantum hardware may be able to tackle some of the problems that are too difficult for ordinary computers. But despite these expectations and the ongoing effort of the research community, reliable quantum computers are not yet realized in a lab setting.

The transition to electric vehicles (EVs) reduces vehicle emissions to combat climate change. EVs raise concerns regarding the production of lithium-ion batteries and related emissions; while batteries can also provide energy storage services for the electricity system.

Cardiovascular diseases (CVDs) are the leading global cause of mortality. Endothelial dysfunction, an early reversible stage of CVD development, is marked by decreased nitric oxide production linked to Ca2+ influx in endothelial cells.

De werkgroep community & communicatie fungeert als koepel die – naast de eigen activiteiten – met alle drie de werkgroepen werkt aan de community- en communicatiegerelateerde aspecten van hun activiteiten

Promotie

Ontdek de uitzonderlijke prestaties en bijdragen van onze academici en onderzoekers, die nationale en internationale erkenning hebben ontvangen voor hun werk in diverse geesteswetenschappelijke disciplines. Leer meer over hun invloedrijke onderzoek en impact binnen de academische gemeenschap en daar…

Wil je een volledige academische opleiding? Dan ga je na je bachelor door met een masteropleiding. Met een masterdiploma op zak heb je meer kans op een baan op academisch niveau. Na afronding krijg je de titel Master of Arts (MA).

This PhD-thesis analyses the relationship between the parties’ choices in the CPB Netherlands Bureau for Economic Policy Analysis’ assessments of the election manifestos and coalition agreements over the period 1986-2017, and tries to explain this relationship.

The research provides insight into disease behavior in both rural and semi-urban areas in Serengeti in Tanzania.

Binnen de opleiding Midden-Oostenstudies kun je je richten op zes verschillende deelgebieden.

Promotie

Promotie

Oorlog en terrorisme overschaduwen de aandacht voor het pre-Islamitisch erfgoed van het Arabisch schiereiland. Het nieuwe Leiden Centre for the Study of Ancient Arabia wil een breed publiek bewust maken van de antieke geschiedenis in deze regio.

In Israël is bij een opgraving van een synagoge bij Horvat Kur een prachtige ingelegde vloer blootgelegd. In de verweerde steentjes van het gevonden mozaïek staat nog duidelijk de naam ‘El’azar’ the lezen. Leidse onderzoeker Jürgen Zangenberg was samen met een groep studenten betrokken bij de opgraving.…

De YAL laat zich horen over beleidskwesties.

De meest bijzondere afbeeldingen, kledingstukken en andere unieke voorwerpen uit de vier eeuwen tellende geschiedenis van de universiteit zijn nu te zien bij ‘Celebrating Curiosity’. Vier stukken uit deze expositie uitgelicht.

Lezing, Studium Generale

Striga hermonthica, commonly known as witchweed, infests major cereal crops in Sub-Saharan Africa causing severe yield losses and threatening the livelihood of millions of resource poor farmers.

Promotor: Prof.dr. M. Ubbink

Early time-resolved experiments by Frauenfelder on the ensemble of the kinetic rebinding of CO to myoglobin molecules resulted in a stretched exponential relaxa-tion due to a very large spread of the reaction rates of individual molecules.

Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.

We investigate the buildup of galaxies from various vantage points. The first two chapters focus on the stellar content of galaxies, especially the distribution of stellar masses at birth and potential variations therein in various galactic environments.

We developed the bitterling as a unique, well-studied model organism in the area of the evolutionary ecology of brood parasitism. The bitterling-mussel relationship, interspecific mussel host preference, and mussel gill structure are studied in detail, to help understand the developmental adaptation…

A New Technology-Based Firm (NTBF) is a significant enabler of job creation and a driver of the economy through stimulating innovation.

De Young Academy Leiden heeft een bestuur bestaande uit een voorzitter en een vicevoorzitter. Daarnaast wordt de YAL ondersteund door een projectmanager en een student-assistent.

Als alumnus van de Universiteit Leiden kunt u uw hele leven lang gebruik blijven maken van de Universitaire Bibliotheken Leiden (UBL).

Promotor: Prof.dr. M. Danhof, Co-Promotor: J. de Jongh

The Standard Model (SM) of particle physics fails to explain several observed phenomena and is incomplete. In order to resolve this problem, one may extend the SM by adding new particles.

One of the key quests in astronomy is to study the growth and evolution of galaxies across cosmic time. Radio observations provide a powerful means of studying the formation of stars and subsequent buildup of distant galaxies, in a way that is unbiased by the presence of dust.

Humans and songbirds learn their vocalizations early in life by exposure to the vocalizations of adult conspecifics. Often, better learning outcomes are achieved with live, social, tutors than with audio-only exposure to vocalizations.

Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: L.H. Heitman

Multiple stars, that is two or more stars composing a gravitationally bound system, are common in the universe.

Promotor: A.H. Meijer, Co-promotor: B.E. Snaar-Jagalska

The present thesis focuses on the pharmacological concept of drug-target interaction, which dates back to the beginning of modern pharmacology.

Promotores: Prof.dr. C.A.M.J.J. van den Hondel, Prof.dr. V. Meyer (Technische Universität Berlin)

According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).

The plant hormone auxin plays a central role in the growth and development of plants. Auxin acts in a concentration dependent manner and polar cell-to-cell transport of this hormone determines its distribution in the tissues of plants. This polar auxin transport is mediated by several families of auxin…

Detecting planets during their formation stages is crucial for understanding the history and diversity of fully developed planetary systems like our own. However, observing young planets directly is challenging because they are often deeply embedded within their host protoplanetary discs, rich in gas…

Creating information portals for support of European environmental policy.

Multi-objective evolutionary computation aims to find high quality (Pareto optimal) solutions that represent the trade-off between multiple objectives.

Microbiome composition of the spermosphere and the rhizosphere of wild and modern bean accessions grown in an agricultural and a native soil from Colombia was characterized by metagenomics and cultivation-dependent approaches.