The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.

Promotor: Prof.dr. A.W. van der Vaart

Promotor: K.J. Batenburg

Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek

Promotor: A. Achúcarro, Co-Promotor: J.W. van Holten

Promotor: K. Kuijken, Co-Promotor: H. Hoekstra

In this dissertation, the synthesis and characterization of a series of iron complexes based on different ligand platforms are described.

Promotor: J. Kuiper

Traditional drug discovery approaches have been hampered by (in vitro) cell-culture models that poorly represent the situation in the human body.

The redox-conversion reaction of metal-disulfide and metal-thiolate complexes are important, as they may shed light on electron-transfer reactions that often occur in Nature.

This thesis explores the theoretical and observational properties of distant massive galaxies that harbour active black holes in their centres and shine brightly at radio wavelengths.

Promotor: A. Achúcarro, Co-promotor: A. Boyarsky

Cathodic corrosion is a relatively unknown phenomenon that can severely etch metallic electrodes at cathodic (negative) potentials.

This thesis is about augmented reality (AR). AR is commonly considered a technology that integrates virtual images into a user’s view of the real world.

In this thesis we study bistable reaction-diffusion equations on lattice domains.

Promotor: W. T. F. den Hollander, F. H. J. Redig

In this article, Samuels focuses on the active fostering of subjunctivity in processes of narrative worldmaking. Drawing extensively from the narrative of an HIV‐positive woman in Indonesia, she shows that by subjunctively leaving open multiple narrative trajectories and future possibilities, individuals…

Balsaminaceae is a diverse plant family characterized by a huge floral morphological diversity.

This thesis considers multi-prover commitment schemes whose security is based on restrictions on the communication between the provers.

This thesis describes the genetic and prokaryotic diversity of giant barrel sponges.

In this PhD-thesis several new and existing data science application are described that are particularly focused on applications for tax administrations.

Promotor: S.M. Verduyn Lunel, Co-promotores: M.F.E. de Jeu, B. de Pagter

Promotor: Prof.dr. M.L. van Heck, Co-Promotor: B.P. Tighe

To address the fundamental questions of how life on Earth emerged and how common life may be in the Universe, it is crucial to know the chemical composition of the planet-forming material.

Inverse problems are problems where we want to estimate the values of certain parameters of a system given observations of the system. Such problems occur in several areas of science and engineering. Inverse problems are often ill-posed, which means that the observations of the system do not uniquely…

Promotor: J.M. van Ruitenbeek, Co-Promotor: S.J. van der Molen

This thesis addresses the chemical processes that determine the compositions of giant planet atmospheres.

Promotor: R. Tijdeman, Co-promotor: H.J.J. te Riele

Promotores: Prof.dr. J. A. Bouwstra, Prof.dr. W. Jiskoot

Shape and biological function are tightly connected. Physical descriptions are used to connect the shape of a biological system with its function.

The applications of studying the early development of insects range from agriculture to material science.

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

Hydrodesulfurization (HDS) is an ubiquitous part of oil refining that ensures that fuels are cleaned of impurities and environment release of pollutants such as SOx and NOx gasses are minimized.

The effective treatment of tuberculosis (TB) remains a major challenge to global health.

Promotores: T.H. Oosterkamp, N. de Jonge

Graphene nanoribbons (GNRs) are used as a current carrying substrate in investigation of current-induced forces in a low-temperature STM (chapter 2).

The application of nanomaterials in industrial processes and consumer products provides many societal benefits, but can also lead to the release of nanomaterials into the environment. The work in this dissertation aims to provide insights into the potential environmental impacts that may follow from…

In some condensed matter systems, such as the surface of a 3D topological insulator, the electrons are effectively massless and we must necessarily use the massless Dirac equation to describe them.

Promotor: Prof.dr. H.J.M. de Groot, Co-promotor: Francesco Buda

We showed that constitutive and inducible chemical and morphological defenses against Western flower thrips differ between tomato and chrysanthemum plants.

Promotores: B. van de Water; P. Hogendoorn; J. Bovée Co-Promotor: E.H.J. Danen

In this thesis, we focus on novel proteins/mechanisms that regulate integrin-adhesion mediated mechano-transduction.

Promotor: Prof.dr. W.J.G.M. Peijnenburg

Errors are everywhere, and mechanical failures are especially common: buckled grain silos and cracked support columns are, justly, seen as an issue to be avoided.

This thesis focuses on amyloid proteins, a class of proteins that convert into amyloid fibrils.

Over the past years it has been discovered that the population of extra-solar planets is large and diverse.

CMLCA is a software tool that supports the technical steps of the Life Cycle Assessment. The focus of the program is on advanced computational aspects of life cycle inventory calculations.

Promotores: P. Stevenhagen, L. van Geemen Co-promotor: R.M. van Luijk

Promotor: S.J. Edixhoven Co-promotor: L. van Geemen, P. Parent

Neuraminidases are enzymes that cleave glycosidic linkages of sialic acid. These enzymes are involved in influenza infections as well as in many cellular processes in mammals and micro-organisms.