2,446 zoekresultaten voor “european been” in de Publieke website
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Impacts of the use of Natural Resources and Products
Development of an aggregated impact indicator to measure decoupling.
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BIOMOT: Motivational strength of ecosystem services and alternative ways to express the value of biodiversity
Do sustainability values play a role in motivating people to act for biodiversity in successful projects and in successful leadership action? And how could these values be incorporated in current economic valuation methods?
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Internationalisering
Als universiteit staan we met beide benen in de wereld. Internationalisering zit in het Leidse DNA: Het ideaal van de vrije academie heeft sinds de oprichting van onze universiteit altijd wetenschappers en studenten van over de hele wereld aangetrokken en dat blijft het doen.
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Effects of light at night on plants and their interactions with other species
What is the effect of light at night on plant phenology and physiology, and how does this affect plant interactions with other species?
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Towards High Performance and Efficient Brain Computer Interface Character Speller: Convolutional Neural Network based Methods
A P300-based Brain Computer Interface character speller, also known as P300 speller, has been an important communication pathway, under extensive research, for people who lose motor ability, such as patients with Amyotrophic Lateral Sclerosis or spinal-cord injury because a P300 speller allows human-beings…
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Probing new physics in the laboratory and in space
The Standard Model (SM) of particle physics fails to explain several observed phenomena and is incomplete. In order to resolve this problem, one may extend the SM by adding new particles.
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Revealing the nature of new low-frequency radio source populations
It has now been well established that shocks and turbulent motions in the intra-cluster medium (ICM) generated through cluster mergers can produce large-scale synchrotron emission.
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The Demographics of Protoplanetary Disks: from Lupus to Orion
The work presented in this thesis is based on ALMA surveys of protoplanetary disks in three star-forming regions: Lupus, OMC-2, and NGC 2024.
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Inhibitors and probes targeting mannanases
This thesis describes the synthesis and biochemical evaluation of a variety of cyclophellitol based activity-based probes and inhibitors targeting various endo- and exo-acting retaining glycosidases. In the last two decades a variety of probes and inhibitors for (hemi)cellulose degrading enzymes have…
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Ab initio molecular dynamics calculations on reactions of molecules with metal surfaces
Promotor: Prof.dr. G.J. Kroes
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Young suns and infant planets: Probing the origins of solar systems
Even though more than 4000 extra-solar planets are known today, only a small fraction of these has been captured in an image. To better understand the planet formation mechanisms in solar-like environments we started the Young Suns Exoplanet Survey (YSES).
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Novel pharmacometric techniques to quantify the pharmacodynamics of analgesics
The overarching clinical aim of this thesis was to improve pharmacological pain management by characterizing the pharmacodynamics of analgesics. This promotion has been awarded the predicate cum laude.
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Role of non-homologous end-joining in T-DNA integration in Arabidopsis thaliana
Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater
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Redox Interconversion between Metal Thiolate and Disulfide Compounds
In the last decade, the redox interconversion between metal thiolate and disulfide compounds has been extensively investigated for copper, but not for other transition metal ions.
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The chlorine chain study
A substance flow analysis, covering about 99 % of the flows of chlorinated substances in the Netherlands.
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Cyclophellitol analogues for profiling of exo- and endo-glycosidases
To this day, all cyclophellitol-based inhibitors and ABPs have been close analogues of their natural substrate counterparts. As a result, these probes showed high selectivity towards their target glycosidases.
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Microfluidic 3D cell culture for high throughput screening
There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.
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Enlightening the Primordial Dark Ages
This thesis is dedicated to the exploration of the primordial dark ages: unknown physics during the earliest stages of the Universe’s expansion that have not yet been directly probed by observations. Cosmic inflation is a burst of exponential expansion of space after the “Big Bang”.
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Engineering of antigen-saving dissolving microneedles for intradermal vaccine delivery
The intradermal administration route is attractive for vaccine delivery, because of the highly populated antigen-presenting cells in the skin. However, the skin’s main physical barrier, the stratum corneum, prevents vaccines from entering the skin.
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Synthetic Methodology Towards ADP-Ribosylation Related Molecular Tools
Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.
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Unsprayed field margins: effects on environment, biodiversity and agricultural practice
A management strategy has been developed for field margins to reduce pesticide drift to non-target areas and to promote biodiversity on arable land. To this end, 3 and 6 m wide strips along the edges of winter wheat, sugar beet and potato crops have been left unsprayed with herbicides and insecticides…
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Cholesterol metabolism in mouse models of atherosclerosis and adrenal steroidogenesis
Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.
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Abiotic depletion in LCIA
Possible improvements for the assessment of abiotic depletion in LCA.
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Novel factors modulating AGC kinase signaling-controlled polar auxin transport
The PID-directed shift in PIN polarity has been broadly accepted as one of the essential mechanisms for the regulation of auxin transport polarity.
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Onderzoeksvragen
De in de introductie geschetste ontwikkelingen leiden ertoe dat huishoudens meer verantwoordelijk gaan dragen voor sociale risico’s, meer zelf moeten plannen, over een langere periode en onder meer onzekerheid.Dit geldt niet alleen in Nederland, maar ook in andere westerse landen. Dit leidt tot de onderstaande…
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Systems diagnosis of chronic diseases, explored by metabolomics and ultra-weak photon emission
Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang
- Summer School: "Manuscript Studies: Codicology and Digital Techniques" (5 ECTS)
- Geluidsversterking, liften
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Towards the development of synthetic vaccines against tuberculosis
The research described in this Thesis was aimed at designing and synthesizing nature-inspired compounds as part of TB vaccine discovery.
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Learning class-imbalanced problems from the perspective of data intrinsic characteristics
The class-imbalance problem is a challenging classification task and is frequently encountered in real-world applications. Various techniques have been developed to improve the imbalanced classification performance theoretically and practically.
- Master International Relations and Diplomacy
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Single-molecule microscopy in zebrafish embryos
Single-Molecule Microscopy (SMM) techniques constitute a group of powerful imaging tools that enable researchers to study the dynamic behavior of individual molecules.
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SFA of PVC in Sweden
In this study the flows of PVC and its additives through the Swedish Society were followed from the cradle to the grave (from production to waste treatment).
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Bouw camera voor Europese reuzentelescoop gaat van start
Leidse wetenschappers gaan een bijdrage leveren aan de ontwikkeling van een camera voor de in aanbouw zijnde European Extremely Large Telescope. Op 28 september tekende de Nederlandse Onderzoekschool voor Astronomie een samenwerkingsovereenkomst met de European Southern Observatory.
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BioSustain
Examining the sustainability aspects of biotechnology, especially those related to the production of ethanol from biomass.
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Pesticides Atlas, Pilot Study
Description of Atlas of the surfacewater concentrations of pesticides in the Netherlands, a pilotstudy.
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'Level Up' to reconnect European society for a higher level of democracy
Level Up is a non-profit project led by a multi-disciplinary team of doctoral researchers in the framework of the Europaeum Network was founded by the University of Oxford University. Sophie Veriter explains the importance of Level Up, the development of the ‘Level Up Toolkit’, and why this project…
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The European Precariat: The Protection of Precarious Workers in the European Union
Promotie
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20th century changes in the Dutch flora
Description of 20th century changes in the Dutch flora: Description and interpretation (1999 - 2005)
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Development of life cycle assessment for residue-based bioenergy
Wat zijn de belangrijkste thema's in het uitvoeren van systemen voor bio-energie ?
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Alumni vanuit Brussel: ‘Universiteit Leiden heeft hier een fantastische reputatie’
Ze droomden van Brussel, werkten hard en uiteindelijk lukte het: werken voor Europa. De lijst met alumni van de Universiteit Leiden in Brussel is lang. Julia Gencheva en Vincent Míča vertellen over hún baan in Brussel en roepen iedereen op om te stemmen. ‘De beslissingen beïnvloeden ook jouw dagelijkse…
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Bernhard Brandl
Wiskunde en Natuurwetenschappen
brandl@strw.leidenuniv.nl | +31 71 527 5830
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Inkomen verdeeld, trends 1977-2019
Op 14 oktober 2021 is het publieksboek uitgekomen. Sindsdien kunnen alle bestanden en links via deze website geraadpleegd worden.
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Online Course EU Policy & Implementation: Making Europe Work!
In this top-rated course, you will learn how the European Union prepares and decides on policy, and how policy is transferred to member states and implemented by various authorities. It discusses the challenges of the European multi-level governance structure and the main causes of policy failure or…
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Economic value of non-timber forest products among Paser Indigenous People of East Kalimantan
Promotor: G.A. Persoon, Co-promotor: H.H. de Iongh
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Evaluating Asian aquaculture using Life Cycle Assessment (LCA)
Are there significant differences among the environmental impacts resulting form the production of Asian aquaculture commodities and what are the main causes for these?
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To explore the drug space smarter: Artificial intelligence in drug design for G protein-coupled receptors
Over several decades, a variety of computational methods for drug discovery have been proposed and applied in practice. With the accumulation of data and the development of machine learning methods, computational drug design methods have gradually shifted to a new paradigm, i.e. deep learning methods…
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Studies on molecular basics of metabolic syndrome in zebrafish
The research described in this thesis has, using the zebrafish as a model system, shed new light on the intricate relationship between TB and DM2, in particular on the role of leptin, SHP-1 and glucocorticoids.
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Macrophages inhibit human osteosarcoma cell growth after activation with the bacterial cell wall derivative liposomal muramyl tripeptide in combination
CONCLUSION: This study demonstrates that human macrophages can be induced to exert direct anti-tumor activity against osteosarcoma cells. Our observation that the induction of macrophage anti-tumor activity by L-MTP-PE required IFN-gamma may be of relevance for the optimization of L-MTP-PE therapy in…
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Onderzoek
Het Instituut Bestuurskunde van de Universiteit Leiden is één van de grootste en oudste instituten voor academisch onderzoek en onderwijs op het gebied van Bestuurskunde in Nederland. Het instituut combineert een wereldwijd goede academische reputatie met een centrale positie voor internationale, nationale,…