1,152 zoekresultaten voor “induced pluripotent system cees” in de Publieke website
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Endoglin and the immune System
Promotie
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Regulation of actomyosin contraction as a driving force of invasive lobular breast cancer
In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).
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Impact of plant hormones on growth and development of actinobacteria
Plants are colonized by an astounding number of microorganisms that can provide different life-support functions, including nutrient acquisition and protection against (a)biotic stresses like drought or pathogen attack.
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Photosynthetic light reactions at the gold interface
Promotor: T.J. Aartsma, Co-promotor: R.N. Frese
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Using insertional mutagenesis to identify breast cancer drivers and therapy resistance genes in mice
In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.
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Global distribution patterns of distinct mycorrhizal types and ecological drivers of these patterns
What are the global relationships between environmental conditions and abundance of distinct types of mycorrhizal fungi in soil and plant roots?
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Prediction of spatial-temporal brain drug distribution with a novel mathematical model
A novel mathematical model describes spatial-temporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.
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Inhibitor discovery of phospholipases and N-acyltransferases
In this thesis an activity-based probe was discovered that could visualize the activity of PLAATs. With an optimized gel-based ABPP assay in hand, screening of a compound library led to the discovery of alpha-ketoamides as a hit for PLAAT3.
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Global Fields and Their L-functions
Artin L-functions associated to continuous representations of the absolute Galois group G_K of a global field K capture a lot of information about G_K as well as arithmetic properties of K.
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Linking soil microbial community dynamics to N2O emission after bioenergy residue amendments
Vinasse is a major by-product generated by the sugarcane biofuel industry. It is a source of microbes, nutrients and organic matter and often it is recycled as fertilizer.
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Lipid bilayers decorated with photosensitive ruthenium complexes
Promotor: Prof.dr. E. Bouwman, Co-promotor: S. Bonnet
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Dynamics and regulation of the oxidative stress response upon chemical exposure
The focus of the described research in this thesis is on the oxidative stress response (Nrf2 pathway). The aim of the research presented in this thesis is to obtain more information concerning microRNAs which are involved in the Nrf2 pathway, to determine and evaluate the application of microRNAs for…
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Activity-based protein profiling in drug discovery
In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.
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Inhibitor Selectivity: Profiling and Prediction
Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.
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Feodor-Lynen onderzoeksbeurs voor Bela Bode
Dr. Bela Bode ontvangt van de Alexander von Humboldt-stichting de Feodor Lynen onderzoeksbeurs voor de ontwikkeling van nieuwe methoden voor verbetering van het signaal in de vaste stof NMR. Hij streeft naar een specifiek analytisch instrument voor oppervlakte-studies en onderzoek over membranen en…
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Interactions of nutrients and pesticides and their effects on aquatic macrofauna
Can we distinguish the effects of pesticides from other abiotic and biotic factors that occur in the field? And how do these factors interact with pesticides?
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Gintingan in Subang: An Indigenous Institution for Sustainable Community-Based Development in the Sunda Region of West Java, Indonesia
This study attempts to understand how indigenous community institutions pose an important role in sustainable community-based development, including the integration between local culture and development.
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Can traditional forest management protect and conserve ironwood (ulin) stands? An option and approach in East Kalimantan
Promotores: G.A. Persoon, H.H. de Iongh
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On the Emergence of the Energy Transition
The energy system is at the heart of two of the greatest challenges of the 21st century: decreasing CO2 emissions to meet the ambitions of the Paris agreement while fulfilling the growing energy demand associated with the economic aspirations of a growing world population.
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An Algebra for Interaction of Cyber-Physical Components
Modeling and analysis of cyber-physical systems are still challenging. One reason is that cyber-physical systems involve many different parts (cyber or physical), of different nature (discrete or continuous), and in constant interaction via sensing and actuating.
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Accountable Artificial Intelligence: Holding Algorithms to Account
Artificial intelligence algorithms govern in subtle, yet fundamental ways, the way we live and are transforming our societies. The promise of efficient, low‐cost or ‘neutral’ solutions harnessing the potential of big data has led public bodies to adopt algorithmic systems in the provision of public…
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Glucocorticoid modulation of the immune response
Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.
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Automated machine learning for dynamic energy management using time-series data
Time-series forecasting through modelling sequences of temporally dependent observations has many industrial and scientific applications. While machine learning models have been widely used to create time-series forecasting models, creating efficient and performant time-series forecasting models is…
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Dynamical Gibbs-non-Gibbs transitions: a study via coupling and large deviations
Promotores: F.H.J. Redig, W.T.F. den Hollander
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Exploration of the endocannabinoid system using metabolomics
Promotie
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Indigenous Peoples and Regional Human Rights Systems
Congres/symposium
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Visualization of effector protein translocation from Agrobacterium tumefaciens into host cells
In our research protein translocation from Agrobacterium into yeast and plant cells is studied to obtain fundamental insights in the translocation process
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Schijnconstructies en intra EU arbeidsmigranten (werkzaam in Nederland)
Het seminar op 30 november jl. over schijnconstructies en intra EU arbeidsmigranten trok veel belangstellenden en was een succes. Deze bijeenkomst werd georganiseerd vanuit het onderzoeksproject Solidarity under Strain (SOLID), onderdeel van de Research Focus Area 'Interaction between Legal Systems…
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When materials become critical: lessons from the 2010 rare earth crisis
Promotor: G.J. Kramer Co-Promotor: E.G.M. Kleijn
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Calculated Moves: Generating Air Combat Behaviour
By training with virtual opponents known as computer generated forces (CGFs), trainee fighter pilots can build the experience necessary for air combat operations, at a fraction of the cost of training with real aircraft.
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Geometry of Vegetation Pattern
One of the effects of climate change is the phenomenon of desertification, a process that occurs in semi-arid and arid areas and causes land degradation as well as vegetation loss. Due to the lack of resources, vegetation self-organizes to sustain itself by forming large-scale spatial patterns.
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Twaalf ILS subsidievoorstellen gehonoreerd voor onderzoek
Twaalf Leidse onderzoekers ontvangen restgelden in het kader van ILS 2.0. Met dit onderzoeksgeld kunnen zij zich richten op het voorbereiden van subsidievoorstellen en het ontwikkelen van nieuwe onderzoekslijnen.
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Development of life cycle assessment for residue-based bioenergy
Wat zijn de belangrijkste thema's in het uitvoeren van systemen voor bio-energie ?
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Transport coefficients and low energy excitations of a strongly interacting holographic fluid
In this thesis, classes of strongly interacting quantum field theories, have been studied.
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High-resolution integral-field spectroscopy of exoplanets
This thesis describes the implementation and on-sky demonstration of high-resolution integral-field spectroscopy for extreme adaptive optics systems that are used to find and characterize exoplanets.
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Predicting the future: Predictive control for astronomical adaptive optics
The field of exoplanet research is rapidly advancing through the development of new technology, observing techniques, and post-processing methods.
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Current challenges in statistical DNA evidence evaluation
Promotor: R.D. Gill, F. Taroni
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Casting light on the ƞ Carinae puzzle
Promotor: Prof.dr. V. Icke, Co-Promotor: T.I. Madura
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Applications of paramagnetic NMR spectroscopy for protein research
The aim of the research presented in this thesis was to develop new methods forchallenging systems in liquid-state NMR using paramagnetic effects generated by thetwo-armed probe CLaNP-5.
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Zipping into Fusion
Promotor: Prof.dr. J.G.E.M. Fraaije, Co-promotor: A. Kros
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Analysis of sub-visible particles in complex injectable formulations
Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik
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Services on Environmental Statistics and Accounts
What is the best way to combine the environmental and economic data and how can we create an operational system to do so, thereby supporting the delivery of data to the Data centres on Products and Resources?
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Dynamical Gibbs-non-Gibbs transitions and Brownian percolation
Promotor: Prof.dr. W.Th.F. den Hollander, Co-promotor: R. Fernandez.
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Presentatie van het e-SIDES project door Magdalena Jozwiak
Op 21 september gaf Magdalena Jozwiak, onderzoeker bij eLaw - Centrum voor Recht en Digitale Technologie, een presentatie over het e-SIDES project tijdens een ILS Lunch Seminar.
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ILS 2.0: De winnende drie voorstellen 2016-2020
Het profileringsgebied Interaction between Legal Systems is multidisciplinair en stimuleert innovatief onderzoek met een inhoudelijke focus op de interactie tussen rechtsstelsels. Voor de komende onderzoeksperiode 2016-2020 zijn uit alle inzendingen drie winnende projecten geselecteerd.
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Onderzoek
Het Instituut Politieke Wetenschap heeft een zeer divers onderzoeksprogramma. Dit programma dient twee doelen: het bevorderen van de eenheid van het Instituut als een intellectuele gemeenschap van sociale wetenschappers en politicologen en om collega’s met overlappende interessegebieden in staat te…
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ILS PhD workshop data visualisation
Op vrijdag 24 maart gaf prof: Amanda Perry-Kessaris (Kent Law School) een korte workshop over data visualisation voor de promovendi van de afdeling Economie. Tijdens deze workshop werden de promovendi uitgedaagd om door middel van LEGO hun onderzoek te visualiseren. Amanda Perry-Kessaris gaf daarna…
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On topological properties of massless fermions in a magnetic field
Make more fluid: In condensed matter systems, electrons can acquire unusual properties from their interaction with the atomic lattice.
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The Great Collapse
Promotor: Prof.dr. S.F. Portegies Zwart
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Translational Symmetry Breaking in Holographic Strange Metals
In this thesis, we have used numerical approaches to study the effects of translational symmetry breaking on strange metallic systems as realised by the holographic duality.