1,285 zoekresultaten voor “induced pluripotent system cell” in de Publieke website
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Composition and function of integrin adhesions
Integrins play an essential role in multicellular life by connecting cells to the extracellular matrix.
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Instituut voor Informatica aan de Universiteit Leiden
Leiden Institute of Advanced Computer Science (LIACS)
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Discrete tomography for integer-valued functions
Promotor: S.J. Edixhoven, Co-promotor: K.J. Batenburg
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Development of synthetic procedures towards immunostimulating carbohydrates
Promotor: Prof.dr. G.A. van der Marel, Co-Promotor: J.D.C. Codée
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Fermions and Bosons: Excitons in strongly correlated materials
Promotors: Prof.dr. J. Zaanen, Prof.dr.ir. H. Hilgenkamp
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Single-cell immune profiling of atherosclerosis
Promotie
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Red cell transfusion in critically ill patients
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Imaging of alkyne-functionalized ruthenium complexes for photoactivated chemotherapy
In photoactivated chemotherapy (PACT), a biologically active compound is caged by a light-cleavable protecting group.
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Investigations on the role of impaired lysosomes of macrophages in disease
The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.
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CO2 reduction on post-transition metals and their alloys: an industrial approach
This thesis focuses on the synthesis, characterization and performance towards CO2 electroreduction of mono and bi-metallic particles based on p-block metals
- Onderzoeksfaciliteiten
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A chemical biology approach for targeting of ligand-drug conjugates
Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: R.G. Boot
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Nucleosome stacking in chromatin fibers probed with single-molecule force- and torque-spectroscopy
In human cells, a meter-long DNA is condensed inside a micrometer-sized cell nucleus. Simultaneously, the genetic code must remain accessible for its replication and transcription to functional proteins.
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Less is more: reduced mycelial heterogeneity for improved production of enzymes and antibiotics
Hoe kan de techniek van cell wall engineering worden ingezet zodat de industrie streptomyceten beter kunnen verwerken tot nieuwe antibiotica?
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The impact of climate variability on the ecology of a lion (Panthera leo Linnaeus 1758) population and lion livestock conflicts in the Amboseli
Promotor: Prof.dr. G.R. de Snoo, Prof.dr. G.A. Persoon, Co-promotor: H.H. de Iongh
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Long term dynamics of stochastic evolution equations
Promotor: S.M. Verduyn Lunel, Co-promotor: O. van Gaans
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Determining the most appropriate dose metrics for evaluating dose-response relationships of metal-based nanoparticles to Zebrafish embryos
Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver
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Matching, entropy, holes and expansions
In this dissertation, matching, entropy, holes and expansions come together. The first chapter is an introduction to ergodic theory and dynamical systems.
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Metabolic signatures in nutrition and health: short-term diet response, sexual dimorphism and hormone chronobiology
The power of personalized nutrition lies in being able to conduct clinical research on healthy people while capturing metabolic markers sensitive to the impact of environmental and metabolic stressors (e.g. diet, changing sex hormones and the menstrual cycle).
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Soil and crop management options to improve nitrogen cycling on dairy farms on peat soil
The main research question of this thesis was: Can nitrogen cycling on dairy farms on peat soil in the Dutch Green Heart area be improved by adapting management to the nitrogen supply from soil and by using other grassland species and crops without affecting milk production?
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Don't Blink: Detecting transiting exoplanets with MASCARA
This thesis describes the Multi-site All-Sky CAmeRA (MASCARA), which consists of two small robotic telescope designed to detect exoplanets around the brightest stars in the sky.
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Applications of multisource data-based dynamic modeling to cell-cell signaling and infectious disease spreading
Promotie
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Vasculaire en Regeneratieve Geneeskunde
Behandelmethoden voor chronische ziekten zijn beperkt. Artsen en onderzoekers van het Leids Universitair Medisch Centrum (LUMC) en de Universiteit Leiden werken aan nieuwe therapieën als alternatief voor orgaantransplantatie. Doel is om organen te herstellen in hun oorspronkelijke functie en op die…
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Laboratoria Digital Archaeology
De onderzoeksgroep Digital Archaeology beheert twee computerlaboratoria voor verschillende doeleinden: een onderwijslab en een onderzoekslab.
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Click to Release for Immunce Cell Activation
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Genetic-Tracing of CD8+ T cell fate decisions
Promotie
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Software
Image-Pro Plus, ImageJ, Cell Profiler, R, Knime en NIS-elements
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Activity-Based Proteasome Profiling
Promotor: Prof.dr. H.S. Overkleeft
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Prediction of brain target site concentrations on the basis of CSF PK: impact of mechanisms of blood-to-brain transport and within brain distribution
Promotor: M. Danhof, Co-promotor: E.C.M. de Lange
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Bioorthogonal Labeling Tools to Study Pathogenic Intracellular Bacteria
In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.
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Precision modeling of breast cancer in the CRISPR era
The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.
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Circulating cells as biomarkers in cardiovascular disease : the difference between men and women
Promotor: J. Kuiper
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Exploitation of host chemokine signalling by pathogenic mycobacteria
Promotores: A.H. Meijer, H.P. Spaink
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Towards understanding the toxicity of copper nanoparticles in aquatic ecosystems
Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver
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Photocleavable activity-based acid glucosylceramidase probes
Lysosomal acid glucosylceramidase (GBA1) is a lysosomal enzyme that degrades glucolipids with its main substrate being glucosylceramide (GlcCer). Defects in the GBA1 gene lead to glycosphingolipidosis Gaucher disease (GD), in which the hydrolysis of GlcCer is impaired and therefore, it accumulates in…
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Antibiotic Discovery: From mechanistic studies to target ID
The investigations described in this thesis lay out strategies aimed at advancing antibiotic research and development. The examples presented revolve around two main approaches: understanding drug-target interactions and target identification.
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Mechanical and genetics basis of cellularization and serosal window closure in Tribolium castaneum
The applications of studying the early development of insects range from agriculture to material science.
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The role of the Arabidopsis AHL15/REJUVENATOR gene in developmental phase transitions
This thesis describes the functional analysis of the Arabidopsis AHL15 gene.
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The role of the interleukin 12 family in atherosclerosis
Promotor: Johan Kuiper, Co-promotor: Saskia C.A. de Jager
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Histone-DNA assemblies in archaea. Shaping the genome on the edge of life
All life on earth contains DNA, which is used to store biological information. Organisms compact their DNA in order for it to fit inside their cell(s).
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Bioorthogonal chemistry to unveil antigen processing events
The research described in this thesis focused on the use of bioorthogonal antigens to investigate immunological processes in antigen presenting cells. Bioorthogonal antigens are antigenic proteins produced through recombinant expression in a methionine auxotrophic E. coli strain.
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Gene Networks-based Mechanistic Assessment of Drug-induced Organ Toxicity
Promotie
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Het legaliteitsbeginsel en de doorwerking van Europees recht in het Nederlandse materiële strafrecht
Het recht van de Europese Unie beïnvloedt direct en indirect de reikwijdte van strafrechtelijke aansprakelijkheid in Nederland. Die beïnvloeding heeft betekenis voor het materieelrechtelijk legaliteitsbeginsel.
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Estimation and Optimization of the Performance of Polyhedral Process Networks
Promotor: Prof.dr.ir. E. Deprettere
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A cycle of life of T cell activation
Oratie
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The use of activity based protein profiling to study proteasome biology
Promotor: H.S. Overkleeft, Co-Promotor: B.I. Florea
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Targeting of antigen-presenting cells with mannosylated conjugates
This thesis describes the development of a variety of mannosylated conjugates. Antigen presenting cells bear mannoside recognizing receptors that actively transport antigen into the cell. This thesis exploits this feature for the development of improved vaccines.
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A bioorthogonal chemistry approach to the study of biomolecules in their ultrastructural cellular context
In this thesis the combinatorial use of bioorthogonal labelling and Electron Microscopy (EM)-based imaging techniques is explored to enable observations of specific molecular targets in their ultrastructural context within the cell.
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A multicolor map of NK and T cell diversity
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Single-cell mechanics for disease biology and pharmacology
Promotie