Every organisms in the tree of life faces the same challenge: the length of its DNA exceeds the volume of the cell it needs to fit in. Several strategies have evolved to solve this problem, one of them being the expression of proteins that bind and organize the DNA.

Dissolving microneedles are a subgroup of microneedle types that completely dissolve within the skin. During this dissolving process the vaccine, stored in the needle matrix, is released into the skin.

Three major cosmology-focused missions are planned for the next decade: the Euclid space telescope, the Vera C. Rubin Observatory in Chile, and the Nancy Grace Roman Space Telescope.

Promotores: J. Jonkers, K.E. de Visser

Galaxy intrinsic alignments induce a major astrophysical contamination to weak gravitational lensing measurements and need to be modelled and mitigated when extracting cosmological information from such measurements.

Promotor: Prof.dr. P. Stevenhagen

CMLCA is a software tool that supports the technical steps of the Life Cycle Assessment. The focus of the program is on advanced computational aspects of life cycle inventory calculations.

Promotor: H.W. Lenstra

This thesis discusses several questions regarding the double ramification cycle as a Chow class on the moduli space of stable n-pointed genus g curves using tools from so-called logarithmic geometry.

Promotor: P. J. J. Hooykaas, Co-promotor: R. Offringa

Promotores: F.H. van Lunteren, F.P. Israel

Promotor: S.M. Verduyn Lunel, Co-promotor: O. van Gaans

Promotores: J.N. Kok, H.J. Hoogeboom

Promotor: Prof.dr. J. Kuiper

Promotor: Prof.dr. T. Hankemeier, Co-promotor: Theo Reijmers

Promotores: P. Stevenhagen, L. van Geemen Co-promotor: R.M. van Luijk

Promotores: Prof.dr. J. Kuiper, Prof.dr. P.H.A. Quax, Co-promotor: I. Bot

Thermodynamics is one of the founding scientific pillars that has helped us better understand heat engines, biology, ecosystems, and even black holes. While it fundamentally describes large systems by examining the bulk behavior of their constituents, it is anchored in the statistical equivalence of…

The way organisms develop from the initial single-cellular state to a complex final assembly like the human body, and how the final body is maintained throughout life, is one of the greatest mysteries and it’s understanding one of the biggest scientific challenges.

This Thesis describes a strategy to synthesize 1,2-cis-oligosaccharides modulated by additives, such as dimethylformamide (DMF), triphenylphosphine oxide (Ph3P=O) and N-methyl(phenyl)formamide (MPF), using building blocks that carry solely benzyl type protecting groups and are therefore of uniform r…

Promotor: C.J. ten Cate

This Thesis focuses on the design and synthesis of ADP-ribosylated compounds that can be applied in biological studies.

Promotor: S.J. Edixhoven, Co-promotor: R.S. de Jong

Promotor: T. H. Oosterkamp

Promotor: Ed F. Deprettere, Co-promotor: Todor P. Stefanov

Hydrogen fuel cells are expected to be pivotal in the energetic transition towards renewable energy sources such as solar and wind power. However, their industrial scalability is severely hindered by the high cost and degradation rate of platinum catalysts, one of their key components. Addressing this…

Electron microscopy has become an extremely important techniquein a wide variety of elds.

One of the effects of climate change is the phenomenon of desertification, a process that occurs in semi-arid and arid areas and causes land degradation as well as vegetation loss. Due to the lack of resources, vegetation self-organizes to sustain itself by forming large-scale spatial patterns.

De YAL laat zich horen over beleidskwesties.

Hieronder vind je de antwoorden op een aantal veelgestelde vragen over toelating tot de klinische specialisaties van de Master Psychologie.

The ultimate aim of this project (initiated by the European Law Institute) is to design a framework that will enable the further development of coherent and functional rules for business rescue in Europe.

We are very excited to announce our Sustainability Series for 2023-2024. Each month an interactive workshop will be organised that discusses a specific theme of sustainability. Interested about sustainability? Do not hesitate to sign up to our events !

Studying the impact of urbanisation on the respiratory health of past Dutch populations (1200-1850 CE).

In september 2012 verscheen onder redactie van T. Bosch en L. Wessels het boek 'Nationalisme, naties en staten. Europa vanaf circa 1800 tot heden'. Dit fraai uitgegeven werk (704 blz.) is een product van de samenwerking tussen de Open Universiteit en Uitgeverij Vantilt.

Een twintigtal Nederlandse politicologen buigt zich over de oorzaken, gevolgen en vooruitzichten van het algemeen kiesrecht in Nederland. Liep Nederland voorop of juist achteraan bij de invoering van kiesrecht voor mannen en iets later voor vrouwen? Hoe hebben burgers de afgelopen eeuw gebruik gemaakt…

Het einde van politieke levens: hoe verlaat je de politiek?

De nieuwe regering in Nieuw-Zeeland tornt aan oude afspraken en verworven rechten van de Maori. In een brandbrief aan koning Charles vragen zij hem om hulp. Hoogleraar Wonu Veys vertelt er meer over bij OVT.

The main goal of this thesis is to achieve advanced control of binding properties in bis-pyrrolic and macrocyclic pyrrolic receptors by light.

Het belang van literatuur voor het recht en de rechtsvinding is op uiteenlopende wijzen geduid. Door het lezen van literatuur leren wij de abstracte en levenloze categorieën, wetten en principes van het juridisch systeem te overstijgen. Dat zou noodzakelijk zijn, uit oogpunt van de rechtvaardigheid.

De Covid-19 pandemie heeft laten zien dat volksgezondheid niet altijd heilig is voor gelovige burgers. Er bestaat bij gelovigen een zekere spanning tussen de religieuze loyaliteiten en hun verantwoordelijkheid voor de volksgezondheid.

Op 18 september 2019 verdedigde Huw Llewellyn zijn proefschrift 'An Institutional Perspective on the United Nations Criminal Tribunals: Governance, Independence and Impartiality'. Het promotieonderzoek is begeleid door promotoren prof.dr. N.M. Blokker en prof.dr. L.J. van den Herik.

In this special edition of Information Polity there is a focus on the transparency challenges of using algorithms in government in decision-making procedures at the macro-, meso-, and micro-levels.

This dissertation presents a new perspective on the life, work and character of the Dutch physical chemist Jacobus Henricus van ’t Hoff, first recipient of the Nobel Prize in Chemistry, and one of the most important and colourful scientists in Dutch history. The image of Van ’t Hoff that emerges from…

A substance flow analysis, covering about 99 % of the flows of chlorinated substances in the Netherlands.

Promotor: G.A. Persoon, Co-promotor: H.H. de Iongh

In this thesis, we will utilize embryonic zebrafish tumour models to understand the interaction between engrafted human cancer cells and macrophages from the host, test drug administration modalities and anti-cancer efficacies of newly-developed PDT and PACT compounds, and test a light-triggered liposomal…

Subproject of the ERC project 'Challenging the Liberal World Order from Within: The Invisible History of the United Nations and the Global South'.

The research described in this thesis has, using the zebrafish as a model system, shed new light on the intricate relationship between TB and DM2, in particular on the role of leptin, SHP-1 and glucocorticoids.

Promotores: F.H.J. Redig, W.T.F. den Hollander

The aim of our research program is to better understand the aetiology and course of mood, anxiety and trauma and stressor-related disorders and to test and improve treatments for these disorders.