1,526 zoekresultaten voor “rene werkt in role environmental” in de Publieke website
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Nicolas Navarre
Wiskunde en Natuurwetenschappen
n.h.navarre@cml.leidenuniv.nl | +31 71 527 2727
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Susan van den Brink
Wiskunde en Natuurwetenschappen
s.van.den.brink@cml.leidenuniv.nl | +31 71 527 2727
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Mining and environmental protection in Indonesia: Regulatory pitfalls
Promotie
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Helen Pluut
Faculteit Rechtsgeleerdheid
h.pluut@law.leidenuniv.nl | +31 71 527 5386
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Ecological functioning of bacterial chitinases in soil
Promotores: Prof.dr. H. van Veen & Prof.dr. W. de Boer (Wageningen University)
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Structural and functional analysis of proteins involved in natural product biosynthesis and morphological differentiation in Streptomyces
Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.
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Time is of the essence: investigating kinetic interactions between drug, endogenous neuropeptides and receptor
Promotor: A.P. IJzerman Co-promotor: L.H. Heitman
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Shining Light on PAHs in Space
Polycyclic aromatic hydrocarbons (PAHs) are the most abundant class of organic compounds in space. The PAH field evolves from the constant interaction between experimentalists, theorists, modellers and observers. While laboratory research and quantum chemical calculations together set up the molecular…
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The good? The bad? The mutant! Characterization of cancer-related somatic mutations and identification of a selectivity hotspot in adenosine
G protein-coupled receptors (GPCRs), one of the largest families of membrane proteins, are responsive to a diverse set of physiological endogenous ligands including hormones and neurotransmitters.
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Growth-induced self-organization in bacterial colonies
Mechanical forces are known to play an important role in bacterial colonies. In this dissertation, we study the self-organization at various stages of growing bacterial colonies, and focus on the mechanical effects of cell growth.
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Lipid signaling and inflammation: metabolomics for better diagnosis and treatment strategy
Lipid signaling is an essential biological event/process in a plethora of pathophysiological conditions. The underlying idea of this thesis is that many of the roles and the complex interplay of the individual signaling lipids in inflammatory processes and related conditions in health and disease is…
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Light Weighed: On the Statistics and Systematics of Weak Gravitational Lensing
In astronomy, the interpration of observations and measurements plays a crucial role: we rely purely and fundamentally on the information that reaches us as observers. And 80% of all matter in the universe is undetectable directly.
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The effects of burying beetle social behaviours on interspecific interactions
This ecological community has long been known to affect host biology, and their diverse roles have been further clarified in recent years following numerous studies of animal:microbiota interactions in diverse systems.
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Cathodic corrosion
Cathodic corrosion is a relatively unknown phenomenon that can severely etch metallic electrodes at cathodic (negative) potentials.
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Development of human skin equivalents to unravel the impaired skin barrier in atopic dermatitis skin
Promotor: J.A. Bouwstra Co-promotor: A. El Ghalbzouri
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Chemical tools to monitor and control proteasome activities
Promotores: H.S. Overkleeft; G.A. van der Marel Co-Promotor: B.I. Florea
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Diversity in the globally intertwined giant barrel sponge species complex
This thesis describes the genetic and prokaryotic diversity of giant barrel sponges.
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The environmentally-regulated interplay between local three- dimensional chromatin architecture and gene expression
Nucleoid associated proteins maintain the architecture of the bacterial chromosome and regulate gene expression, hinting that their role as transcription factors may involve local three-dimensional chromosome re-modelling.
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Immunity in atherosclerosis: novel assays, biomarkers and therapeutic approaches
Atherosclerosis is a progressive disease resulting in the formation of an arterial plaque. Despite lipid lowering, recurrent cardiovascular events remain a risk. While atherosclerosis is primarily lipid-driven, the immune system plays a critical role in the pathophysiology.
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Resistance to PARP inhibition by DNA damage response alterations in BRCA1/2-deficient tumors
Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.
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Computational modeling of cellular dynamics in tumor cell migration
Epithelial-mesenchymal plasticity (EMP) and tumor cell migration play an important role in cancer progression, and an improved understanding of the mechanisms underlying these concepts is essential for developing new targeted approaches.
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Soil legacy effects on aboveground plant-insect interactions
In this thesis, the role of plant-mediated soil legacy effects in shaping aboveground plant-insect interactions was investigated.
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Noonan and LEOPARD syndrome in zebrafish: molecular mechanisms and cardiac development
Promotor: Prof.dr. J. den Hertog
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Cellular Forces: Adhering, Shaping, Sensing and Dividing
Promotor: Prof.dr. T. Schmidt
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The symmetry of crystals and the topology of electrons
Promotor: J. Zaanen, Co-Promotor: V. Juricic
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Innate immune modulation in atherosclerosis and vascular
Promotores: Prof.dr. J. Kuiper, Prof.dr. P.H.A. Quax, Co-promotor: I. Bot
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Agenda dynamics in the European Union : the interaction between the European Council and the European Commission in the policy domain of organized
The European Council and the European Commission have a similar role in agenda setting. Both place issues on the EU agenda. However, these institutions have distinct designs. They have different political attributes (the European Council has considerably more political authority) and information-processing…
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Protein arginine methyltransferases as modulators of lipid metabolism and inflammation and the relevance for atherosclerosis
Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…
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Affinity-based profiling of the adenosine receptors
The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.
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Advanced in vitro models for studying drug induced toxicity
Promotor: B.van de Water, Co-promotor: L.S.Price
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Flows of six heavy metals
Can we provide the Dutch government with an integrative framework, wherein the various policies can be placed and the need for further measures can be identified?
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Green defense against thrips- Exploring natural products for early management of western flower thrips
As a contribution to the changing legislation and evolving societal attitudes concerning environmental issues, this project aims to enhance and manipulate the plants’ own natural defense mechanisms against western flower thrips (WFT).
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Cryo Electron Tomography Studies On Bacterial Chemosensory Arrays
Bacterial chemosensory arrays are protein assemblies that are the key structural and functional component for motile bacteria to sense their internal or environmental chemical signals.
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Ontmoet onze medewerkers - Werken bij de Universiteit Leiden
Hoe is het om te werken bij de Universiteit Leiden en hoe zijn wij als werkgever? Diverse medewerkers delen graag hun ervaringen. Bekijk de video’s.
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Wat werkt bij het voorkomen van sociale angst?
Programma's die de symptomen van sociale angst bij kinderen willen verminderen, omvatten doorgaans meerdere onderdelen, zoals blootstelling en mentale herstructurering. Het is onbekend of afzonderlijke onderdelen positieve effecten opleveren bij kinderen of dat een combinatie van onderdelen nodig is…
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Het Experiment Resultaatgerelateerde Beloning – verwachtingen over werking en doelbereiking
Samen met co-auteur M. De Jong schreef Willem van Boom een bijdrage over het Experiment resultaatgerelateerde beloning en of dat experiment aan zijn doel zal beantwoorden.
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Autisme werkt!
Werknemers met autisme zorgen voor diversiteit in een bedrijf. Daarbij komen de positieve eigenschappen van veel mensen met autisme naar boven. Daarom is het thema van de Autismeweek 2019 van de Nederlandse Vereniging voor Autisme (NVA): Autisme werkt! PhD Lisa van Klaveren vertelt hoe onderzoek naar…
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PhD: sustainability & circularity-based decision support systems (industrial digital twins)
Wiskunde en Natuurwetenschappen, Centrum voor Milieuwetenschappen Leiden (CML)
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Transfusion Medicine and Cellular and Tissue Therapies (MSc)
This joint Master with the Autonomous University of Barcelona will the equip you with the necessary competences to play a key role in the emerging field of transfusion medicine. The programme includes both transfusion of blood components and hematopoietic transplants, cellular and tissue therapy, and…
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Public lecture: 'The ocean’s role in mitigating climate change'
Lezing
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EXIOBASE
EXIOBASE is a global, detailed Multi-regional Environmentally Extended Supply and Use / Input Output (MR EE SUT/IOT) database. It was developed by harmonizing and detailing SUT for a large number of countries, estimating emissions and resource extractions by industry, linking the country EE SUT via…
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Jaarverslag CML 2013 - 2014 (English)
In 2013-2014, CML published over 100 papers, contributed to various international sustainability debates, renovated our building and educated thousands of students from all over the world through our MOOC. These accomplishments and many more are highlighted in this booklet, CML wish you a pleasant…
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Multifaceted role of the complement system in health and disease
Promotie
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Role of intestinal microbiota in cardio-metabolic disease
Promotie
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Seeing voices: the role of multimodal cues in vocal learning
Promotie
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Microvasculature in Microfluidics: matching complexity with compatibility
In vitro disease models play a fundamental role in drug research. They enable the systemic identification and validation of disease mechanisms and the discovery of possible drug targets. However, more than often, drug candidates that are identified in vitro fail in the later clinical stages of drug…
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Online Course International Law in Action: The Arbitration of International Disputes
This course explores international arbitration as one of the most common methods of international dispute settlement. You will gain an in-depth understanding of international arbitration through the analysis of its role as a mechanism of dispute settlement, its institutions, the fields of law it is…
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Online Course International Law in Action: A Guide to the International Courts and Tribunals in The Hague
This course explains the functions of each international court and tribunal in The Hague. On the basis of cases and interviews with judges and lawyers, this course explores the role of these courts and tribunals and their potential to contribute to global justice.
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Metagenomics for community ecology; a next generation of eDNA monitoring tool for biomass studies in freshwater environments
How can we quantify the density of species within a community through environmental DNA concentrations?
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Onderzoek
Steden, Voedsel, Water, Biodiversiteit, Bronnen en Energie: dit zijn de belangrijkste onderzoeksthema’s voor het CML. Ons doel is altijd om wereldwijd voorop te lopen in ons vakgebied. En echte impact te hebben met onze onderzoeksprogramma’s.