1,453 zoekresultaten voor “state cell biology” in de Publieke website
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Computational Modeling of Cellular Dynamics in Tumor Cell Migration
Promotie
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Deciphering myeloid (progenitor) cell function and communication in (tumor) tissues
Promotie
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Amoeboid cell migration and physicochemical properties of the extracellular environment
Promotie
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Perspectives on decision making in hematopoietic stem cell transplantation
Promotie
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Targeting of antigen-presenting cells with mannosylated conjugates
This thesis describes the development of a variety of mannosylated conjugates. Antigen presenting cells bear mannoside recognizing receptors that actively transport antigen into the cell. This thesis exploits this feature for the development of improved vaccines.
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A bioorthogonal chemistry approach to the study of biomolecules in their ultrastructural cellular context
In this thesis the combinatorial use of bioorthogonal labelling and Electron Microscopy (EM)-based imaging techniques is explored to enable observations of specific molecular targets in their ultrastructural context within the cell.
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The hunt for frozen organic molecules in space
Complex Organic Molecules (COMs) have been detected in objects across different stages of stellar evolution.
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Chemical genetic approaches for target validation
Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.
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Inducing spin triplet superconductivity in a ferromagnet
Promotor: J. Aarts
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The Function of Toll-like receptor 2 in Infection and Inflammation
The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.
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Bioorthogonal Antigens as Tool for Investigation of Antigen Processing and Presentation
In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…
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Treosulfan pharmacokinetics and dynamics in pediatric allogeneic stem cell transplantation
Promotie
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Postdoc: Algorithmic developments to automatically detect RiPP structural features
Wiskunde en Natuurwetenschappen, Instituut Biologie Leiden (IBL)
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Nico Schrijver benoemd als arbiter Terugtrekkingsakkoord EU-VK
Nico Schrijver emeritus hoogleraar Internationaal Publiekrecht en staatsraad bij de Raad van State is door de Europese Unie en het Verenigd Koninkrijk benoemd als lid van het arbitragepanel dat bevoegd is om geschillen te beslechten over het terugtrekkingsakkoord EU-VK.
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Towards the development of synthetic vaccines against tuberculosis
The research described in this Thesis was aimed at designing and synthesizing nature-inspired compounds as part of TB vaccine discovery.
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Morphogenesis and protein production in Aspergillus niger
Promotores: C.A.M.J.J. van den Hondel, V. Meyer, Co-promotor: A.F.J. Ram
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Inverse design of curvature-sensing antiviral peptides
Viral diseases constitute one of the major challenges in modern medicine. Membrane-targeting have broad-spectrum potential and could distinguish viral membranes from the host cell plasma membrane by the difference in membrane curvature.
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Play by the rules? : coordination of EU sustainable development policies and the importance of the politico-legal context
There is an increasing amount of attention on EU and its Member States contributions to implementation of two landmark agreements: the Paris Climate Agreement and the UN Agenda 2030 with Sustainable Development Goals (SDGs). Absent from the current literature is an analysis of the political effect of…
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In vitro investigation of the photoprotection mechanism of Light Harvesting Complex II
Solar energy is used by photosynthetic organisms to drive energy required cellular processes. Is absorbed by two groups of pigments, located in the LHCs.
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The effects of burying beetle social behaviours on interspecific interactions
This ecological community has long been known to affect host biology, and their diverse roles have been further clarified in recent years following numerous studies of animal:microbiota interactions in diverse systems.
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Inverse electron demand Diels-Alder pyridazine elimination: synthetic tools for chemical immunology
The inverse electron demand Diels-Alder (IEDDA) pyridazine elimination emerged in 2013 as a new bioorthogonal reaction and constitutes a prime example of what is now known as dissociative bioorthogonal chemistry. The research described in this Thesis aims to develop synthetic strategies which enable…
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Monitoring and detection of nanomaterials in biological media.
How do nanoparticles bioaccumulate and biodistribute in organisms?
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Towards artificial photosynthesis: resolving supramolecular packing of artificial antennae chromophores through a hybrid approach
Promotor: H.J.M. de Groot
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Stimulated Raman Adiabatic Passage in Optomechanics
In the thesis we demonstrated an 85% state transfer efficiency between two mechanical modes coupled to a common optical mode via stimulated Raman adiabatic passage (STIRAP) in the classical regime. We also showed possibilities to manipulate quantum states of the mechanical modes via STIRAP.
- Livestream diploma-uitreiking Msc Biology (sessie 2)
- Livestream diploma-uitreiking Msc Biology (sessie 2)
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Anjali Pandit
Wiskunde en Natuurwetenschappen
a.pandit@chem.leidenuniv.nl | +31 71 527 4198
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Huub de Groot
Wiskunde en Natuurwetenschappen
groot_h@chem.leidenuniv.nl | +31 71 527 4539
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Capillary Electrophoresis-Mass Spectrometry based Metabolomics Approaches for Volume-restricted Applications
Metabolomics is a powerful tool that can provide a comprehensive insight into the complexity of human biology and the pathophysiology of diseases. By analyzing the metabolome, which refers to the complete set of small (endogenous) molecules (with a mass <1500 Da) present within a given biological system,…
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Biodiversity and Sustainability (MSc)
In deze opleiding streef je naar het beantwoorden van biologische vraagstukken in relatie tot milieu, ecologie en andere maatschappelijk relevante onderwerpen.
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Molecular Genetics and Biotechnology (MSc)
Deze opleiding integreert genetica, moleculaire biologie en biotechnologie in een aantrekkelijk programma met uitstekende carrièreperspectieven.
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Evolutionary Developmental Biology of Bitterling Fish
Promotie
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Exploring Ubiquitin and ISG15 Biology with Chemical Tools
Promotie
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Accelerating the Photocatalytic Water Splitting in Catalyst−Dye Complexes
As a virtually inexhaustible source, solar energy plays a major role in future global energy scenarios.
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Ecology of the Ethiopian wolf in a changing landscape: Human carnivore interactions in Afroalpine ecosystems of Ethiopia
Do Ethiopian wolves change their diet and foraging strategy in the landscape under different land uses? How land use affect Afro-alpine rodent Communities? How important are Afro-alpine natural resources utilisation for local livelihoods? What is the human perception of conflict in the Afro-alpine a…
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Targeting tumors using T-cell receptor gene transfer
Promotie
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Merlijn van Weerd over krokodillen op Filipijnen bij Vroege Vogels
Het was lange tijd één van de meest bedreigde diersoorten ter wereld. Ruim tien jaar geleden dacht men zelfs nog dat hij was uitgestorven: de Filipijnse krokodil.
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Development of novel anti-cancer strategies utilizing the zebrafish xenograft model
In this thesis, we will utilize embryonic zebrafish tumour models to understand the interaction between engrafted human cancer cells and macrophages from the host, test drug administration modalities and anti-cancer efficacies of newly-developed PDT and PACT compounds, and test a light-triggered liposomal…
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Blowup in the complex Ginzburg-Landau equation
Promotor: Prof.dr. A. Doelman, Co-promotor: V. Rottschäfer
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Quantum local asymptotic normality and other questions of quantum statistics
Promotor: R. Gill, Co-promotor: P. Massart
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NMR Faciliteit
Met de NMR faciliteit doen we onderzoek naar de synthese van paramagnetische moleculen om kennis te vergaren over de structuur en dynamiek van eiwitten. Deze kennis kan dienen als basis voor een medicijn dat zich hecht aan een eiwit of voor de ontwikkeling van vaccins. Medicijnontwikkeling is één van…
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Asia and the UN
Subproject of the ERC project 'Challenging the Liberal World Order from Within: The Invisible History of the United Nations and the Global South'.
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Systems pharmacology of the endocannabinoid system
In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).
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The diverse roles of integrin α3β1 in cancer: Lessons learned from skin and breast carcinogenesis
In this thesis, we aim to shed light on the diverse and often opposing roles of integrin α3β1 in cancer.
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Development of an in vitro vascular network using zebrafish embryonic cells
One of the major limitations in culturing complex tissues or organs is the lack of vascularization in the cultured tissue. Development of a functional capillary bed could overcome this problem.
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Force sensing and transmission in human induced pluripotent stem-cell-derived pericytes
Pericytes, the mural cells of blood microvessels, are important regulators of vascular morphogenesis and function that have been postulated to mechanically control microvascular diameter through as yet unknown mechanisms.
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Mechano-transduction mediated by integrin-based adhesion complexes: integration of cytoskeleton and adhesion dynamics
In this thesis, we focus on novel proteins/mechanisms that regulate integrin-adhesion mediated mechano-transduction.
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Functional fluorescent materials and migration dynamics of neural progenitor cells
In this thesis, time-lapse fluorescent microscopy plays a pivotal role in investigating functional materials within living cells as well as the migratory behaviour of neural progenitor cells.
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Bioorthogonal Antigens
The aim of this thesis is to explore the use of Bioorthogonal Antigens to study the cross-presentation pathway.
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Spin-label EPR Approaches to Protein Interactions
Promotor: Prof.dr. E.J.J. Groenen, Co-Promotor: M. Huber