Promotores: Prof.dr. J. Aarts, Prof.dr. J.M. van Ruitenbeek

Promotor: Prof.dr. A. Achucarro

This thesis applies data mining in commercial settings in the telecommunications industry.

This thesis provides explicit expressions for the density functions of absolutely continuous invariant measures for general families of interval maps, that include random maps and infinite measure transformations, not necessarily number systems.

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Understanding the formation and evolution of planetary systems is one of the most fundamental challenges in astronomy. To directly image and study young exoplanets and the circumstellar disks they form from, dedicated high-contrast imaging instruments are built.

This thesis describes the use of a combined approach of computational and experimental techniques to gain novel insights to understand the glycosylation reaction and its reactive intermediates.

Outflows are crucially important for the gas budget and evolution of luminous star-forming galaxies and AGNs, with observed mass outflow rates of the same order as the star formation rate. Greater star formation and black hole growth lead to more intense feedback and outflows, resulting in self-regulated…

The thesis is about the study of shell evolution of the Hydrocenidae of the genus Georissa. This thesis started with a general overview on the evolutionary process of animals due to ecological changes.

This thesis investigates the contribution of quantum computers to machine learning, a field called Quantum Machine Learning. Quantum Machine Learning promises innovative perspectives and methods for solving complex problems in machine learning, leveraging the unique capabilities of quantum computers…

This thesis presents pioneering work on the panchromatic emission of some of the most luminous galaxies in the early Universe: star forming galaxies and active galactic nuclei.

This thesis describes the role of pollution, specifically neonicotinoid insecticides, as an actor of the ongoing biodiversity decline.

Promotor: S.M. Verduyn Lunel, Co-Promotor: O.W. van Gaans

This Thesis focuses on the design and synthesis of ADP-ribosylated compounds that can be applied in biological studies.

In this thesis, the role of mast cells in atherosclerosis and novel therapeutic strategies to inhibit atherosclerosis progression are discussed. The first part of the thesis specifically focuses on the relation between mast cells and advanced human atherosclerotic plaque characteristics.

Universe in a Box is erkend voor zijn educatieve waarde, door het Europese netwerk van Wetenschapseducatie (Scientix).

The work described in this thesis focuses on the development of linear or cyclized peptide probes against protein N-methyltransferases to characterize their specific binding behavior, providing further binding details for inhibitory activity study.

This thesis presents the first synthetic peptides ADP-ribosylated on serine, threonine, tyrosine, arginine and cysteine.

This thesis consists of three chapters, the first two of which concern division points of elements of the multiplicative group of a number field.

In this thesis, the researcher developed a nanosystem based on the metallophilic Interaction between cyclometalated complexes.

This thesis describes the development of a variety of mannosylated conjugates. Antigen presenting cells bear mannoside recognizing receptors that actively transport antigen into the cell. This thesis exploits this feature for the development of improved vaccines.

This thesis consists of five chapters on how to construct prediction sets for different types of data and models in a parametric or nonparametric Bayesian paradigm.

In this thesis we study the moduli space of genus g curves, and the differential forms that occur naturally on this moduli space.

The thesis introduces three methods for high-dimensional prediction problems in the biomedical field. The methods make use of empirical and variational Bayes in the estimation.

The research described in this thesis focused on the preparation of S/N functionalized carbene ligands and their transition metal complexes, and the exploration of their application as electrocatalysts for proton reduction.

Childhood obesity is an increasing health issue. In the first part of this thesis comorbidities in children with obesity were studied, concerning the diagnostic process and dosing regimens.

This thesis investigates how galaxies form and what diversifies the evolutionary histories of galaxies.

This thesis discusses the physical and chemical processes than influence the composition of forming planets.

The focus of the described research in this thesis is on the oxidative stress response (Nrf2 pathway). The aim of the research presented in this thesis is to obtain more information concerning microRNAs which are involved in the Nrf2 pathway, to determine and evaluate the application of microRNAs for…

In the thesis the dynamics of strategies is studied from two perspectives.In the first part of the thesis strategies are considered to be opinions present in a community.

Cryogenic electron microscopy (cryo-EM) is a powerful technique used to visualize the inside of cells and to study specific protein complexes. Within this thesis, I describe the use of various cryo-EM techniques to gain insight into the structural changes of the human pathogen, Vibrio cholerae, as it…

In this PhD-thesis several new and existing data science application are described that are particularly focused on applications for tax administrations.

Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.

In surface science there is great effort to move from studying simple, flat model surfaces in vacuum to investigating more complex model catalysts in gas environments (in situ). This thesis gives three examples of such studies using microscopy and spectroscopy.

Promotor: A. Achúcarro Co-promotor: A. Boyarsky

This thesis describes the design, characterization and application of dextran based crosslinked network.

The main object of study in this thesis is an Arakelov inequalitywhich bounds the degree of an invertible subsheaf of the direct image ofthe pluricanonical relative sheaf of a semistable family of curves.

Promotor: T. Hankemeier, Co-Promotores: T. Reijmers, L. Coulier

This thesis is largely an experimental study on the formation of solid-state simple and complex organic molecules in the H2O-rich and CO-rich ice phases of dense interstellar clouds and dark cores.

In this thesis we have discussed several parameters that affect the electrochemical conversion of enviromentaly harmful molecules such as nitrates and carbon dioxide to more valuable and less deleterious compounds, in order to cast light onto the mechanism of the reaction to achieve an efficient and…

Promotor: W. T. F. den Hollander, F. H. J. Redig

The main subject of this thesis is the design and synthesis of paramagnetic molecules for protein studies with NMR and EPR spectroscopy.

The overall objectives of my thesis are to investigate the dynamics of the sorghum root microbiome and to explore the beneficial effects of the root microbiome on sorghum growth and stress tolerance.

The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.

In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.

There is accumulating evidence for an increase in severe global drought events. In particular, Europe experienced several severe droughts in 2003, 2015, and 2018 (unprecedented in the past 2,110 years). Such droughts have caused serious and far-reaching impacts on terrestrial ecosystems.

In the past decade many population studies have been performed with the Atacama Large Millimeter/submillimeter Array (ALMA) to understand the bulk properties of protoplanetary disks around young stars. These population studies mostly consisted of low mass stars, with relatively few of the disks around…

Majorana fermions in superconductors are the subgap quasiparticle excitations that are their own antiparticles.

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman

Promotor: J.N. Kok, Co-promotor: M.S. Lew