2,492 zoekresultaten voor “fundamentele study” in de Publieke website
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Natural Computing
Het onderzoek in het natural computing cluster omvat theoretische fundamenten, de ontwikkeling van nieuwe algoritmen en interdisciplinaire toepassingen van natuurlijke computermethoden. De drijvende kracht achter hun onderzoek is de missie om het begrip van natuurlijke systemen als rekenmodellen te…
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Galaxies and the structures in which they are embedded
Wetenschappers bij de Leidse Sterrewacht onderzoeken de fundamenteel natuurkundige verschijnselen die voor structuur in het heelal zorgen. Deze processen brengen materie bijeen tot sterrenstelsels en gas bijeen tot sterren. Met behulp van krachtige telescopen en geavanceerde berekeningen en computersimulaties…
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Illuminating N-acylethanolamine biosynthesis with new chemical tools
In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.
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Disentangling drought-responsive traits with focus on Arabidopsis
In recent decades, climate change has led to more frequent and severe drought events, causing serious consequences such as increased forest mortality and significant crop yield losses. Understanding how drought affects plants, especially economically important herbaceous species, is crucial for predicting…
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Class invariants for tame Galois algebras
Promotores: B. Erez, P. Stevenhagen, Co-Promotor: B. de Smit
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Shape Analysis for Phenotype Characterisation from High-throughput Imaging
We have studied shape with a particular focus on the zebrafish model system. The shape is an essential appearance of the phenotype of a biological specimen and it can be used to read out a current state or response or to study gene expression.
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Beyond random and forbidden interactions : how optimizing energy gain results in morphological matching among subalpine Asteraceae and their
Plants and their pollinators form complex interaction networks. Within these networks, species differ widely in the number of species they interact with.
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Inhibitor discovery of phospholipases and N-acyltransferases
In this thesis an activity-based probe was discovered that could visualize the activity of PLAATs. With an optimized gel-based ABPP assay in hand, screening of a compound library led to the discovery of alpha-ketoamides as a hit for PLAAT3.
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Can tigers survive in human-dominated landscapes?
S.S. Kolipaka’s thesis questions and investigates the survival prospects of reintroduced tigers and their offspring’s in the human dominated landscape of Panna tiger reserve in India.
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Parallel evolution in an invasive plant species: evolutionary changes in allocation to growth, defense, competitive ability and regrowth of invasive
Promotor: Prof.dr. P.G.L Klinkhamer, Co-promotor: K. Vrieling
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Crossed product algebras associated with topological dynamical systems
Promotor: S.M. Verduyn Lunel, Co-promotoren: M.F.E. de Jeu, S.D. Silvestrov
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Structural Properties of Single Server Queueing Systems: Efficient Methods via Lumping and Dynamic Programming
This thesis consists of two main parts. The first part (Chapters 2 and 3) deals with a class of Markov process called Quasi-Skipfree (QSF) processes.
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X-ray spectroscopy of interstellar dust: from the laboratory to the Galaxy
In this thesis, we present new laboratory data of interstellar dust analogues.
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Microscopy and Spectroscopy on Model Catalysts in Gas Environments
In surface science there is great effort to move from studying simple, flat model surfaces in vacuum to investigating more complex model catalysts in gas environments (in situ). This thesis gives three examples of such studies using microscopy and spectroscopy.
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Connecting dots between natural and artificial Photosynthesis
Decentralized plug and play systems for energy production are the future picture of our society. Artificial photosynthetic systems are used for this purpose.
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Early death of massive galaxies in the distant universe
Promotor: M. Franx, Co-Promotor: I.F. Labbé
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Molecular electronics: Controlled manipulation, noise and graphene architecture
Atoms and molecules are the basic units of matter. If we keep dividing a bar of gold or a glass of water into smaller parts, at the end we are left with a single gold atom or a water molecule.
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Identifying the origins of galaxy formation
This thesis investigates how galaxies form and what diversifies the evolutionary histories of galaxies.
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The structure of a working catalyst: from flat surfaces to nanoparticles
Promotor: Prof.dr. J.W.M. Frenken
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Systems pharmacology of the endocannabinoid system
In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).
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Dynamics of the Oort Cloud and Formation of Interstellar Comets Santiago Torres Rodriguez
The solar system was formed approximately 4.56 billion years ago. Despite the numerous theories that have been developed over the years, the formation and evolution of the solar system still remain unclear.
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Mononuclear spin-transition materials based on the bapbpy scaffold
Promotor: Prof.dr. E. Bouwman, Co-Promotor: S. Bonnet
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Deepening the uncertainty dimension of environmental Life Cycle Assessment: addressing choice, future and interpretation uncertainties.
LCA has become an important method to study environmental impacts of human activities. Still, there are several methodological issues in LCA that can adversely affect the results reliability.
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Glucocorticoid modulation of the immune response
Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.
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Bakti and Sayan traditions among the Tenggerese people in East Java: the role of indigenous institutions in integrated elderly care development
This research delves into the unique cultural approach of the Tenggerese people, an Indigenous community in East Java, Indonesia, regarding elderly care. It focuses on their traditional practices of bakti (‘filial piety’) and sayan (‘mutual aid’), deeply ingrained in the community's lifestyle and va…
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An Online Corpus of UML design models: Construction and empirical studies
Promotores: J. Kok, M. Chaudron (Chalmers University)
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Abiotic depletion in LCIA
Possible improvements for the assessment of abiotic depletion in LCA.
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The evolution of chemical diversity in plants : pyrrolizidine alkaloids and cytochrome P450s in Jacobaea
Plants produce an astonishing variety of secondary metabolites (SMs) which are thought to play vital roles in the fitness of plants through ecological interactions.
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The impact of sustainable forest management on plant and bird diversity in East Kalimantan, Indonesia
Promotor: G.R. de Snoo, Co-promotor: H.H. de Iongh, C.J.M. Musters
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Internship information
An important part of the SCS specialisation is the internship period. Students will get the opportunity to get to know the field and to apply what they have learned during the courses.
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Optimisation of first clinical studies in special populations: towards semi-physiological pharmacokinetic models
M. Danhof, Co-promotores: J. Freijer, A. Yassen
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WIC-opvarenden (Seafarers of the Dutch West India Company)
Due to the almost complete disappearance of the archive of the Old Dutch West India Company (WIC, 1621-1674) not much is known about the ships and crews of this company. In this project we start the reconstruction of this basic information making use of new digital humanities techniques to extract this…
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Pedagogische Wetenschappen
Hoe ontwikkelen mensen zich en hoe leren ze? Hoe heeft de omgeving invloed daarop? En hoe kunnen we zorgen dat de ontwikkeling zo goed mogelijk verloopt? Wat kunnen we doen als het niet goed loopt? Dat zijn vragen waarop de medewerkers van het Instituut Pedagogische Wetenschappen antwoorden zoeken.
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Science Friction (SciFri)
Hoe kan wrijving op de nanoschaal gereduceerd worden?
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Oncode Accelerator
Nog altijd lukt het niet om alle kankerpatiënten van de juiste behandeling te voorzien. Oncode Accelerator wil daarom de manier waarop we kankerbehandelingen ontwikkelen innoveren: binnen het programma wordt de patiënt centraal gesteld. Universiteit Leiden en LUMC gaan hier samen met andere partijen…
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EU Banking and Insurance Insolvency (tweede druk)
Zojuist verschenen: EU Banking and Insurance Insolvency (tweede druk) Auteurs en redactie: Gabriel Moss QC, Bob Wessels en Matthias Haentjens Uitgever: Oxford University Press
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Visie
Fundamentele kennis die voortkomt uit onderzoek vergroot onze culturele rijkdom en is een belangrijke basis voor de ontwikkeling en vernieuwing van producten, diensten en de inrichting van onze samenleving.
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Onderzoek
Het Instituut Pedagogische Wetenschappen voert onderzoek uit gericht op 6 deelgebieden die gezamelijk het domein dekken van de studie naar normatieve en niet-normatieve ontwikkeling van gedrag, emoties en leren vanaf de jonge kindertijd tot aan de periode van jong-volwassenheid.
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De basis van wetgeving
Door globalisering komen nationale en internationale belastingnormen steeds vaker met elkaar in conflict. Een herziening van de fiscale wetgeving lijkt daarom noodzakelijk. Dat heeft niet alleen te maken met problematiek rondom multinationals, maar ook met veranderende maatschappelijke normen over het…
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Over de opleiding
Tijdens je eerste en tweede jaar werk je aan een stevig fundament in de wiskunde. In het derde jaar en in de master is er veel keuzeruimte om vakken te kiezen in de fundamentele en toegepaste wiskunde.
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Rusland: Een traditie van politieke gevangenschap
Lezing, Studium Generale
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Simona Demková bespreekt mensgerichte aanpak van de EU bij regulering van kunstmatige intelligentie
Op 27 en 28 april nam Simona Demková als panellid deel aan de conferentie ‘A 'Brussels Effect' for EU Digital Governance? Legal, Political and Economic Considerations’. Deze conferentie werd georganiseerd door de Universiteit van Lausanne, de Ecole Polytechnique Fédérale de Lausanne (EPFL), de Rijksuniversiteit…
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Duurzaamheid
De Universiteit Leiden staat midden in de maatschappij en wil bijdragen aan een duurzame samenleving. Verduurzaming van gebouwen levert een bijdrage aan Nederlandse en Europese milieunormen. De Universiteit Leiden houdt daar in al haar bouwprojecten rekening mee.
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Random walks in dynamic random environments
Promotor: W.Th.F. den Hollander
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Noisy Patterns: Bridging the gap between stochastics and dynamics
In this thesis, we study travelling waves in stochastic reaction-diffusion equations. We extend techniques from the deterministic theory for travelling waves to apply to the stochastic version, which allows us to compute the stochastic wave speed and shape, and draw conclusions on the stability of the…
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Causing a stir: Radiative and mechanical feedback in starburst galaxies
Promotores: Prof.dr. F.P. Israel, Prof.dr. P.P. van der Werf
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On the Galois closure of commutative algebras
Promotores: H.W. Lenstra, B. Erez, Co-promotor: L. Taelman
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Imaging polarimetry for the characterisation of exoplanets and protoplanetary discs. Scientific and technical challenges
Promotor: Prof.dr. C.U. Keller
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Anyonic, cosmic, and chaotic: three faces of Majorana fermions
In my thesis I study Majorana fermions from three different perspectives. The first one corresponds to non-interacting Majorana fermions that, however, pose non-trivial topological properties. The second one corresponds to strongly interacting Majoranas and the third to relic neutrinos. No one knows…
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Peptide-based probes for protein N-Methyltransferases
The work described in this thesis focuses on the development of linear or cyclized peptide probes against protein N-methyltransferases to characterize their specific binding behavior, providing further binding details for inhibitory activity study.