The CC chemokine receptor 2 (CCR2), a member of the G protein-coupled receptor (GPCR) superfamily, is widely involved in autoimmune and inflammatory diseases. However, no drugs for this receptor have made it to the pharmaceutical market yet.

Advanced mass spectrometry of glycosphingolipids takes the central stage in this thesis. Investigations focus on characterization of glycosphingolipid metabolism in health and disease with emphasis to the detection and accurate quantitation of known and so far unknown glycosphingolipids and closely…

In this Ph.D. thesis we study the interaction of low energy electrons with thin materials, namely layered materials (graphene, hexagonal boron nitride, molybdenum disulfide) and organic films. At these low energies the quantum mechanical wavelength of the electron wave function is in the order of a…

Most of current public-key cryptography is considered insecure against attacks from sufficiently powerful quantum computers. Post-quantum cryptography studies methods to secure information resistant against such attacks. One proposal is isogeny-based cryptography, which bases its security on computational…

Bacteria are highly complex and diverse organisms that have adapted to survive in ecological niches ranging from the most extreme to the most heterogeneous environments.

This thesis manuscript explores the use of video games as tools for conceptual exploration and academic research.

Promotor: Prof.dr. G.P. van Wezel

This dissertation consists of two parts, with the common theme

Promotor: J. Aarts

In the first part, we introduce a new condition, called toric-additivity, on a family of abelian varieties degenerating to a semi-abelian scheme over a normal crossing divisor.

This dissertation focuses on developing new mathematical and statistical methods to properly represent time-varying covariates and model them within the context of time-to-event analysis.

The expanding population and economic activity are driving up global energy consumption. Simultaneously, there is an urgent need to transition from fossil fuels to renewable sources to mitigate the climate crisis, primarily caused by fossil fuel combustion.

Promotor: A.W. van der Vaart

Promotor: W. T. F. den Hollander, F. H. J. Redig

Majorana fermions in superconductors are the subgap quasiparticle excitations that are their own antiparticles.

This dissertation contains four works during my PhD. Different biomaterials have been designed based on coiled-coil peptides. These biomaterials have a range of applications, inclusing drug delivery, cell sorting to cell-cell fusion.

Promotores: P. Stevenhagen, E. Fouvry (Univeriste Paris Saclay)

The effective treatment of tuberculosis (TB) remains a major challenge to global health.

Actinobacteria are well known for the production of bioactive natural products, many of which have applications in the fields of human, animal and plant health. Subject of this thesis are the anthracyclines, glycosylated aromatic polyketides with potent anticancer activity.

Promotores: J. Jonkers, K.E. de Visser

The focus of this thesis is on the technical methods which help promote the movement towards Trustworthy AI, specifically within the Inspectorate of the Netherlands.

Indonesia is experiencing various environmental challenges related to its fast economic growth. Therefore, it is necessary to have measurable and applicable indicators to obtain accurate data and information regarding the costs of adverse environmental impacts arising from economic activities to support…

In some condensed matter systems, such as the surface of a 3D topological insulator, the electrons are effectively massless and we must necessarily use the massless Dirac equation to describe them.

The elementary excitations of magnets are called spin waves, and their corresponding quasi-particles are known as magnons. The rapidly growing field of Magnonics aims at using them as information carriers in a new generation of electronic devices, (almost) free of electric currents.

Promotor: Prof.dr. E.F. Smets. Co-promotores: B. Gravendeel, F. Pupulin

This thesis describes the genetic and prokaryotic diversity of giant barrel sponges.

The transition to electric vehicles (EVs) reduces vehicle emissions to combat climate change. EVs raise concerns regarding the production of lithium-ion batteries and related emissions; while batteries can also provide energy storage services for the electricity system.

Promotor: J. Zaanen, Co-Promotor: V. Juricic

Promotor: Prof.dr. J. Kuiper

Spectroscopic studies on fluorescent single molecules in organic condensed matter does not only provide information about the molecule itself, but also its near environment. By suppression of phonon-induced broadening of spectral lines through cooling to low temperatures, small changes in the spectral…

Promotor: Prof.dr. W.T.F. den Hollander

Promotores: Prof.dr. J. Kuiper, Prof.dr. P.H.A. Quax, Co-promotor: I. Bot

The International Course on Water Use and Management in Cagayan Valley The Philippines (2011-2015)

Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken

Overall dispersion in LCA as result of inherent uncertainties, spread and unrepresentativeness.

Ice, the solid state of water, plays an important role on our planet as well as the entire universe.Despite the fact that an individual water molecule has a very simple structure, its chemical bonding in the solid phase can be surprisingly complex.

Promotor: Prof.dr. F.S. de Boer, Co-promotor: D. Clarke

Gibbs measures, as used in Statistical Mechanics, have a definition that is remarkably similar to the definition ofg-measures, used in dynamical systems.

Promotor: Prof.dr. R. Verpoorte, Co-Promotores: N.R. Mustafa, A.E. Schulte

Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.

How did African actors engage with the idea of Eurafrica?

Prof. Vriesendorp en prof. Wessels zijn opgenomen in de 2020 Lawdragon 500 Leading Global Restructuring & Insolvency Lawyers. Prof. Haentjens is genoemd in de 2020 Lawdragon Leading Global Restructuring Advisors & Consultants.

Hoe verhoudt gender van leidinggevenden zich tot de tevredenheid van werknemers over het leiderschap van hun direct leidinggevende? In de online Leiden Leadership Lunch op vrijdag 24 september presenteerde Dr. Max van Lent (universitair docent Economie) de resultaten van zijn recente onderzoek naar…

Judi Mesman, decaan Leiden University College en hoogleraar van de interdisciplinaire studie van maatschappelijke uitdagingen, was onlangs te beluisteren bij BNR's Big Five.

Met ingang van 1 mei 2018 is Nicole de Voogd benoemd tot Bijzonder hoogleraar Global Change and Marine Ecosystems bij het Centrum voor Milieuwetenschappen Leiden (CML). Zij is momenteel senior onderzoeker bij Naturalis Biodiversity Center op het gebied van tropische mariene ecosystemen.

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