This dissertation focused on computational methods based on first principles calculations using the Density Functional Theory (DFT) framework. Emphasis was laid on affordable methods that can provide a tradeoff between computational expense and accuracy.

Promotor: E.F. Smets Co-promotor: J. Geml

Bacteria are highly complex and diverse organisms that have adapted to survive in ecological niches ranging from the most extreme to the most heterogeneous environments.

This work is dedicated to interpreting in cohomological terms the special values of zeta functions of arithmetic schemes.

Promotor: Prof.dr. M.K. Richardson

Promotor: Prof.dr. G.P. van Wezel

Overall dispersion in LCA as result of inherent uncertainties, spread and unrepresentativeness.

Promotores: Prof.dr. G.W. Canters, Prof.dr. T.J. Aartsma

Migration imposes special pressures on the meaning, experience and organization of lifecycle rituals. These pressures are felt most strongly by Muslim migrants to Western Europe. In this innovative study, Nathal M. Dessing examines the effects of migration on the life cycle rituals of Moroccan, Turkish…

Herkennen huisartsen kinderen die (een verhoogd risico voor) angststoornissen hebben en is er een patroon dat kan helpen om kinderen met en zonder angststoornissen te onderscheiden in de huisartsenpraktijk?

Hydrogen fuel cells are expected to be pivotal in the energetic transition towards renewable energy sources such as solar and wind power. However, their industrial scalability is severely hindered by the high cost and degradation rate of platinum catalysts, one of their key components. Addressing this…

In 2050 moet de overstap naar nieuwe, duurzame energiebronnen zijn voltooid. Wetenschappers van de Universiteit Leiden verrichten vanuit diverse disciplines uniek onderzoek dat bijdraagt aan deze transitie en de reductie van CO2.

In this top-rated course, you will learn how the European Union prepares and decides on policy, and how policy is transferred to member states and implemented by various authorities. It discusses the challenges of the European multi-level governance structure and the main causes of policy failure or…

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Woensdag 14 juli publiceerden Nederlandse astronomen een primeur in vakblad Nature. Het was hen als eersten ter wereld gelukt om isotopen te ontwaren in de damkring van een exoplaneet. Een ontdekking die ons meer kan leren over het ontstaan van planeten. Verschillende media schreven over de bijzondere…

Twee teams met taalwetenschappers deden onafhankelijk van elkaar onderzoek naar de identiteit van ‘Q’, de persoon van wie wordt verondersteld dat die de complottheorie heeft verspreid. Beide studies lijken te wijzen naar hetzelfde duo.

Promotor: Prof.dr. J. Kuiper

Promotors: Prof.dr. G.R. de Snoo, Prof.dr. G.A. Persoon, Prof.dr.ir. H.H. de Iongh

Promotor: Prof.dr. H.J.M de Groot, Co-Promotor: A. Alia

The key purpose of this project is to study tautological relations on the level of closed differential forms or even integral cochains (i.e. we don't take classes in cohomology).

Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.

Promotores: H.A. Udo de Haes, H.H.T. Prins, Co-promotor: H.H. de Iongh

Promotors: Prof.dr. P.J. Punt, Prof.dr. C.A.M.J.J. van den Hondel

The soil-dwelling, filamentous bacteria of the genus Streptomyces are renowned for their production of useful secondary metabolites including antibiotics. The work described in this thesis provides new insights on the role and regulation of antibiotic production and resistance in these bacteria.

On a structural level, the properties featured by a majority of mechanical metamaterials can be ascribed to the finite number of soft internal degrees-of freedom allowing for low-energy deformations.

Catalysis is of extreme relevance in the production of everyday materials and plays a central role in many aspects of our life.

This thesis systematically studies the physicochemical properties of non-planar, propeller-shaped, polycyclic aromatic hydrocarbons. The synthesis of several so-called propellerenes is described on a gram scale, using optimized procedures aimed at using less hazardous reagents and reducing the amount…

We strive to address the challenge of constructing a modeling language to write software which can take advantage of recent hardware developments (multicore, cloud) without compromising in its abstraction levels.

With increasing carbon dioxide levels in the atmosphere and their detrimental effect on the global climate, modern society needs to push for more renewable energy sources. Storing widely accessible and abundant solar energy in chemical bonds in the form of molecular fuel via artificial photosynthesis…

Promotor: G.P. van Wezel, Co-Promotor: E. Vijgenboom

Hoewel veel Nederlanders inmiddels netjes hun plasticafval scheiden, belandt nog steeds een beduidend deel uiteindelijk in de oceaan, aldus ecoloog Arnold Tukker. In een interview met de New Scientist vertelt hij waar het mis gaat.

Nederland en China kunnen van elkaar leren slimmer om te gaan met afvalwater uit huishoudens en veeteelt. Leidse, Wageningse en Chinese wetenschappers gaan samen met betrokkenen werken aan haalbare oplossingen die milieu, gezondheid en economie vooruit helpen.

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Voordrachten in het kader van het onderzoeksproject Zelfredzaamheid en sociale bescherming over de levenscyclus (aug. 2017 – dec. 2023).

Alastair Reed, universitair docent bij het Institute of Security and Global Affairs (ISGA), is geïnterviewd door Devex, het mediaplatform voor de wereldwijde ontwikkelingsgemeenschap.

Description of Biotic ligand models: making an inventory of available models & assessment of the variability of the predicted HC5 using the BLMs in different Dutch water types (2005 - 2007)

Hoe gaan we in de toekomst energie opwekken zonder nog meer bij te dragen aan de opwarming van de aarde? Industrieel ecoloog René Kleijn spreekt over koolstofarme energie op radio en tv voor het programma Focus, en vertelt erover in de VPRO-gids.

Promotor: Promotor: W.Th.F. den Hollander, Co-promotor: V. Sidoravicius.

Wetland plants are distinguished from plants of other terrestrial ecosystems by their adaptations to specific habitat stresses, including waterlogged and flooding and the subsequent abundance of phytotoxic compounds.

Plants produce an astonishing variety of secondary metabolites (SMs) which are thought to play vital roles in the fitness of plants through ecological interactions.

This thesis focuses on the X-ray spectral analysis of merging galaxy clusters and the plasma code development for future high-resolution X-ray spectroscopy observations.

Promotor: Prof.dr. M. Danhof

Promotor: W. Jaffe, Co-promotor: K. Meisenheimer

Promotor: T. Schmidt

Promotores: Prof. dr. G.R. (Geert) de Snoo, Dr. E. (Ester) van der Voet