This thesis consists of two main parts. The first part (Chapters 2 and 3) deals with a class of Markov process called Quasi-Skipfree (QSF) processes.

Promotores: G.A. Persoon, H.H. de Iongh

Promotor: K.J. Batenburg

Promotor: Prof.dr. L.J. Slikkerveer

We developed the bitterling as a unique, well-studied model organism in the area of the evolutionary ecology of brood parasitism. The bitterling-mussel relationship, interspecific mussel host preference, and mussel gill structure are studied in detail, to help understand the developmental adaptation…

Bacteria often experience external challenges, such as changes in environmental conditions or attacks by bacteriophages.

Statistical considerations guide the design and implementation of the experiments that scientists perform. For instance, in a clinical trial about a the efficacy of a treatment, its effect in a certain minimum amount of patients has to be observed in order to make confident assertions about the efficacy…

In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).

Promotores: Prof.dr. H.J.M. de Groot, Prof.dr. J. Matysik (Universitaet Leipzig)

An important part of the SCS specialisation is the internship period. Students will get the opportunity to get to know the field and to apply what they have learned during the courses.

To an algebraic curve C over the complex numbers one can associate a non-negative integer g, the genus, as a measure of its complexity.

Promotor: P.D. Grünwald

Promotores: Prof.dr. T.H.W. Bäck, Prof.dr. M.R.V. Chaudron, Co-Promotor: M.T.M. Emmerich

The sequence-dependence of biomolecular interactions involving nucleic acids and proteins is essential for numerous processes inside the cell. Insights into the underlying molecular mechanisms have been obtained using various biochemical and biophysical methods on two different levels — bulk and sin…

This thesis considers multi-prover commitment schemes whose security is based on restrictions on the communication between the provers.

Promotor: A. Doelman, Co-promotor: J.D.M. Rademacher

Promotor: Prof.dr. J.W.M. Frenken

The recently introduced nature-originated deep eutectic solvents, so-called natural deep eutectic solvents (NADES) are considered as truly green solvents, which composed of natural ingredients found abundantly in organisms.

Ethiopian wolves are endangered diurnal Afroalpine rodent hunters. I investigated the interaction between wolves, rodents and human land use in Borena Sayint National Park (BSNP), Abune Yosef and Aboi Gara in Ethiopia.

Synthetic microswimmers take an important place within the interdisciplinary field of active soft matter.

Why do black holes emit thermal radiation? And how does a closed quantum system thermalize?

Modeling and analysis of cyber-physical systems are still challenging. One reason is that cyber-physical systems involve many different parts (cyber or physical), of different nature (discrete or continuous), and in constant interaction via sensing and actuating.

Wil je een volledige academische opleiding? Dan ga je na je bachelor door met een masteropleiding. Met een masterdiploma op zak heb je meer kans op een baan op academisch niveau. Na afronding krijg je de titel Master of Arts (MA).

Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency

Plant-microbe interaction resulted in different physio/chemical responses by host plant and interacting rhizobacteria.

Promotor: Prof.dr. T. Schmidt, Co-Promotor: S.J.T. van Noort

Classical statistical methods, such as p-values, are difficult for researchers to apply correctly. They for example do not allow drawing conclusions from a study early, or for extending a study with extra research groups that want to make their data available later.

1. To what extent do metallic NPs added to soil extractions change the activity, abundance, or community composition of microbes? 2. How do the effects of metallic NPs on soil microbes differ from the effects of the ions shedding from corresponding NPs?

With the advent of multicore processors and data centers, computer hardware has become increasingly parallel, allowing one to run multiple pieces of software at the same time on different machines. Coordination of these pieces is best expressed in a coordination language as an explicit interaction protocol…

Despite being the object of intense study, embryonic development has been difficult to model due to a number of reasons. First, complex tissues can be comprised of many cell types, of which we probably only know a subset.

This thesis examines the link between simple molecules and the underlying structure and chemistry within protoplanetary disks - the birthplaces of planets.

The aim of this thesis is to expedite and ensure the systematic accuracy of clearance scaling from adults to paediatric patients, with a special focus on drugs undergoing hepatic metabolism.

We consider the propagation of electrical signals through nerve fibres.

Wil je een volledige academische opleiding? Dan ga je na je bachelor door met een masteropleiding. Met een masterdiploma op zak heb je meer kans op een baan op academisch niveau. Na afronding krijg je de titel Master of Arts (MA).

The research provides insight into disease behavior in both rural and semi-urban areas in Serengeti in Tanzania.

The PID-directed shift in PIN polarity has been broadly accepted as one of the essential mechanisms for the regulation of auxin transport polarity.

A management strategy has been developed for field margins to reduce pesticide drift to non-target areas and to promote biodiversity on arable land. To this end, 3 and 6 m wide strips along the edges of winter wheat, sugar beet and potato crops have been left unsprayed with herbicides and insecticides…

Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.

Op 11 juni 2020 verdedigde Sabine Witting haar proefschrift 'Child Sexual Abuse in the Digital Era: Rethinking Legal Frameworks and Transnational Law Enforcement Collaboration'. Het promotieonderzoek is begeleid door promotoren prof.mr. J.J. Sloth-Nielsen en prof.dr.mr. S. van der Hof.

What is the best way to combine the environmental and economic data and how can we create an operational system to do so, thereby supporting the delivery of data to the Data centres on Products and Resources?

Fungal food spoilage often starts with a contamination with spores. Experimental data strongly indicate the existence of subpopulations of spores with different levels of resistance to preservation methods.

Computers zijn in staat om ongelooflijk nauwkeurige voorspellingen te doen op basis van machine learning. Met andere woorden, deze computers kunnen zonder tussenkomst leren als ze eenmaal door mensen zijn voorgeprogrammeerd. Bij LIACS verkennen en verleggen we de grenzen van wat een revolutionaire nieuwe…

The project

Emeritus hoogleraar Toegepaste Statistiek Jacqueline Meulman ontving het erelidmaatschap tijdens de jaarlijkse bijeenkomt van de Nederlandse Vereniging voor Statistiek en Operations Research (VVSOR). Hiermee is ze het elfde erelid van de vereniging.

Disclaimer: Manuscripten die te maken hebben met het Resilience Center zijn alleen voor academische doeleinden en zijn niet bedoeld voor massaverspreiding of kopiëren. Raadpleeg de toepasselijke wetten voor eerlijk gebruik, inclusief de beperkingen van de houders van auteursrechten op publicaties.

Het Sport Data Center, een consortium van universiteiten waarvan Universiteit Leiden penvoerder is, is erkend als Certified Partner van Sportinnovator. Daarmee wordt het Sport Data Center een belangrijk onderdeel van het Sportinnovator ecosysteem. Sportinnovator is het nationale programma voor sport-innovatie,…

Als je van China naar Siberië migreert, zijn een paar tussenstops geen overbodige luxe. Voor trekvogels zijn ze zelfs cruciaal om te overleven. Maar door klimaatverandering verandert de seizoensgebonden beschikbaarheid van voedsel op deze stops. Milieuwetenschapper Yali Si heeft ontdekt dat vogels daardoor…

Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)

The extensive use of electronic communication channels and other devices has opened new possibilities for collecting data on human behavior. This information is sometimes openly accessible, but largely part of administrative registration systems that are not open to the broader public. The data provides…