In this thesis, the focus lies on studying glucocorticoid receptor dynamics in living cells with the aim of understanding how this transcription factor finds its DNA target sites to regulate transcription.

Promotores: Prof.dr. H. van Veen & Prof.dr. W. de Boer (Wageningen University)

Bacteriophages, or phages for short, are the most abundant biological entity in nature. They shape bacterial communities and are a major driving force in bacterial evolution.

How can we develop and further improve life cycle impact assessment methods, characterisation factors and normalisation factors?

Promotor: I. A. G. Snellen, Co-promotor: M. A. Kenworthy

‘Wie meent rechts- en levensbeschouwing te kunnen scheiden, schaadt beide. Hij vervalst zijn rechtsovertuiging, omdat hij het teruggrijpen op de hoogste waarde stelselmatig vermijdt’, aldus Paul Scholten (1875-1946), één van de grootste, zo niet dé grootste rechtsfilosoof die de Lage Landen hebben v…

Leren van coachen van collega’s en studenten door ervaren docenten

Over het lokaliseren van vermogensschade en de geldigheid van forumkeuzes in het licht van de recente uitspraken Kolassa/Barclays Bank en Profit van het Hof van Justitie van de Europese Unie.

Promotor: M.T.M. Koper, Co-promotors: A.I. Yanson, L.B.F. Juurlink

This thesis focuses on the X-ray spectral analysis of merging galaxy clusters and the plasma code development for future high-resolution X-ray spectroscopy observations.

The use of N fertilizers has increased worldwide in the past century. While this increased input of N has increased food productivity, it has also contributed to decreases in biodiversity, soil quality and environmental health, including increases in greenhouse gas emissions.

1: What is the relative importance of alfa and beta biodiversity in polar ecosystems, and how does intraspecific variation influence this? 2: How can we use remote sensing to determine functional biodiversity (within communities) in polar ecosystems? 3: Temporal and spatial scales of functional biodiversity:…

Al twee eeuwen lang wordt er strijd geleverd over studiefinanciering. Hoe zouden geld en kansen verdeeld moeten worden? In hoeverre mag de staat zich daar mee bemoeien? Wie moet voor studiefinanciering betalen, en wie mag ontvangen? Deze vragen raken aan grote politieke en maatschappelijke verschillen…

Consequences for sediment stability and seston trapping

The largest genus within the Phyllanthaceae family is a group called Phyllanthus L. Recent studies have shown, that Phyllanthus is paraphyletic with the genera Glochidion, Breynia and Synostemon nested within it.

The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.

Promotor: C.A.J. Knibbe, Co-promotor: J.J. Boelens, R.G.M. Bredius

Almost all bacteria are enveloped by a cell wall that provides cellular protection.

Promotores: Prof.dr. B.R. Katzy, Prof.dr. K. Sailer (Munich University)

Promotor: W. Jiskoot, Co-promotor: H.A. Every

This dissertation consists of two parts, with the common theme

Promotor: P.J.J. Hooykaas, Co-Promotor: E.J. van der Zaal

This thesis describes the synthesis and biological evaluation of TLR2/6, TLR4, TLR7/8 and TLR9 ligands, of which the activity can be conditionally controlled.

Stellar feedback is a crucial ingredient in the evolution of galaxies.

Plant diversity is essential for us and our planet as it sustains the stability of our ecosystems, provides vital materials and food to us and supports many ecosystem services.

Promotor: Peter Stevenhagen

Light-Harvesting Complex II (LHCII) is responsible for light absorption and excitation energy transfer in plants and photosynthetic algae, while in high light it undergoes conformational changes by which it quenches excitations to prevent photodamage.

Promotor: J. Schaye

In 2019 bestond de Universiteit Leiden 444 jaar. Deze bijzondere leeftijd vroeg om een bijzondere viering, samen met de inwoners van Leiden en Den Haag. In, met en voor de stad.

This thesis pioneers diatom molecular identification and quantification through genome-scale methods, with four key aims: (i) reviewing DNA/RNA sequencing methods in aquatic biomonitoring to highlight their strengths and limitations;

Promotor: G.R. de Snoo, W. Kustiawan, Co-promotor: H.H. de Iongh

We explored how to morphologically classify well-resolved jetted radio-loud active galactic nuclei (RLAGN) in the LOw Frequency Array (LOFAR) Two-metre Sky Survey (LoTSS) using machine learning.

Promotor: Prof.dr. V. Icke, Co-Promotor: T.I. Madura

Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken

Promotor: Prof.dr. B.R. Katzy, Prof.dr. J. de Vries

Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel

Adenosine is an endogenous ligand which exerts its action by activating adenosine receptors (ARs), while its circulating levels are controlled via a variety of mechanism and proteins, amongst others the equilibrative nucleoside transporters (ENTs).

Promotor: T. Hankemeier, Co-Promotores: T. Reijmers, L. Coulier

The main object of study in this thesis is an Arakelov inequalitywhich bounds the degree of an invertible subsheaf of the direct image ofthe pluricanonical relative sheaf of a semistable family of curves.

The focus of the dissertation

Promotores: H.S. Overkleeft; G.A. van der Marel Co-Promotor: B.I. Florea

The main goal of the research described in this thesis was the development of new photoactivated chemotherapy (PACT) ruthenium(II) complexes bearing a non-toxic photolabile ligand.

Promotores: R. Cramer, A.K. Lenstra, Co-Promotor: B.M.M. de Weger

Promotor: F.H.J. Redig, Co-Promotor: W.T.F. den Hollander

Biological cells, the basic building blocks of all life forms, are surrounded by a lipid membrane. More than half of the membrane is occupied by membrane proteins, which can regulate the cell functionality through specific arrangements.

The aim of this thesis is to develop and study a robust and adaptable scaffold for supramolecular polymer self-assembly in water.

Balsaminaceae is a diverse plant family characterized by a huge floral morphological diversity.

Every organisms in the tree of life faces the same challenge: the length of its DNA exceeds the volume of the cell it needs to fit in. Several strategies have evolved to solve this problem, one of them being the expression of proteins that bind and organize the DNA.

The elementary excitations of magnets are called spin waves, and their corresponding quasi-particles are known as magnons. The rapidly growing field of Magnonics aims at using them as information carriers in a new generation of electronic devices, (almost) free of electric currents.

Op 9 juni 2020 verdedigde Maral Darouei haar proefschrift 'Managing a sustainable career in the contemporary world of work: Personal choices and contextual challenges'. Het promotieonderzoek is begeleid door promotor prof.dr. J.I. van der Rest.