Promotor: H.V.J. Linnartz

Promotor: Prof.dr. W.Th.F. den Hollander, Co-promotor: R. Fernandez.

Protein–protein complexes are formed via transient states called encounter complexes that greatly influence the formation of the stereospecific complex.

Spectroscopic studies on fluorescent single molecules in organic condensed matter does not only provide information about the molecule itself, but also its near environment. By suppression of phonon-induced broadening of spectral lines through cooling to low temperatures, small changes in the spectral…

‘We moeten op zoek naar producten die gewone wegwerpplastics kunnen vervangen, bijvoorbeeld van plantmateriaal. Binnen een jaar of 20 is het gemiddelde plasticgebruik van een huishouden met grote slagen verminderd.’ Volgens Thijs Bosker, Universitair Hoofddocent aan het Leiden University College, in…

Welke hersencel doet wát als bijvoorbeeld de ziekte van Parkinson ontstaat? Het duurt niet lang meer voordat die puzzel stukje voor stukje gelegd kan worden. Computationeel bioloog Ahmed Mahfouz combineert Leidse bio-kennis met Delftse algoritmen en komt steeds dichterbij de sleutel.

This thesis described the development of novel scanning tunneling microscopy techniques to investigate strongly correlated electronic states in quantum matter.

Kidney transplantation is a major advance of modern medicine. This course will give you state of the art updates about what used to be an experimental, risky, and very limited treatment option more than 50 years ago and is now routinely performed in many countries worldwide.

Promotor: A. Kros, Co-promotor: R.R.C.L. Olsthoorn

Supervisor: P.J.J. Hooykaas

Invasive lobular carcinoma (ILC) is the second most common type of breast cancer.

Cardiovascular disease is the leading cause of death worldwide.

Promotor: H.P. Spaink, Co-Promotor: A.H. Meijer

Promotor: P.G.L. Klinkhamer, Co-Promotores: K. Vrieling, P.P.J. Mulder

This thesis describes the synthesis and biological evaluation of TLR2/6, TLR4, TLR7/8 and TLR9 ligands, of which the activity can be conditionally controlled.

The aim is to discover where differently shaped metal nanoparticles distributes in Danio rerio, linking the distribution with genomic responses and so come up with a Mode of Action.

Promotor: Jaap Brouwer, Co-promotor: Remus Th. Dame

The main subject of this thesis is the design and synthesis of paramagnetic molecules for protein studies with NMR and EPR spectroscopy.

Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel

Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.

Promotor: A. Kros

The main goal of the research described in this thesis was the development of new photoactivated chemotherapy (PACT) ruthenium(II) complexes bearing a non-toxic photolabile ligand.

Promotor: T. Schmidt

Biological cells, the basic building blocks of all life forms, are surrounded by a lipid membrane. More than half of the membrane is occupied by membrane proteins, which can regulate the cell functionality through specific arrangements.

Promotor: G.F.A. Kersten, W. Jiskoot, Co-promotor: B. Metz

Every organisms in the tree of life faces the same challenge: the length of its DNA exceeds the volume of the cell it needs to fit in. Several strategies have evolved to solve this problem, one of them being the expression of proteins that bind and organize the DNA.

Promotor: Prof.dr. B. van de Water

Promotor: Prof.dr. B. van de Water

Promotor: G.P. van Wezel, Co-Promotor: E. Vijgenboom

Promotor: Prof.dr. T. Hankemeier, Prof.dr. J.C.T. Eijkel (Twente University)

Atherosclerosis is a progressive disease resulting in the formation of an arterial plaque. Despite lipid lowering, recurrent cardiovascular events remain a risk. While atherosclerosis is primarily lipid-driven, the immune system plays a critical role in the pathophysiology.

In most applications, electrocatalysts exhibit a large surface area to volume ratio, for example using nanoparticles.

Antibiotic resistance, caused by widespread use of antibiotics, leads to bacterial infections that are difficult, if not impossible, to treat and is a major worldwide health concern.

Promotor: P. J. J. Hooykaas, Co-promotor: R. Offringa

Heterogeneous catalysis is one of the fundamental processes of modern life, being common in industrial refinery and hydrogen vehicles, all the way to the living cell. The dissociation of H2 on Cu(111) is an important benchmark system for studying heterogeneous catalysis, with a large and varied amount…

Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.

Promotores: W. Jiskoot, F. Ossendorp

Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.

This thesis describes the use of bioorthogonal proteins in immunological settings. It provides an introduction towards the field of protein modification, which was used throughout the thesis for the expression of proteins containing unnatural amino acids.

Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.

De zeldzame Ethiopische wolf komt steeds vaker in aanvaring met lokale veehouders. Promovendus Girma Eshete zocht naar manieren om het elegante beest te redden van de ondergang. Promotie op 5 september.

Wiskunde en Natuurwetenschappen, Leids Instituut voor Chemisch Onderzoek (LIC)

Promotie

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In het laatste nummer van Tijdschrift voor Geschiedenis (jaargang 125, augustus 2012, nummer 3) publiceren prof.dr. Beatrice de Graaf, Coreline Boot MA en drs. Constant Hijzen een drieluik over hun VIDI-onderzoek 'Enemies of the State. Historicizing security'.

In this top-rated course, you will learn how the European Union prepares and decides on policy, and how policy is transferred to member states and implemented by various authorities. It discusses the challenges of the European multi-level governance structure and the main causes of policy failure or…