Nature, nurture and neural mechanisms of social emotion regulation in childhood

This thesis describes the design, synthesis, and immunological evaluation of varying (neo)antigenic peptide conjugates containing either a TLR2 or a TLR7 agonist.

The objective of this study was to investigate the expression and function of GRHL2 in different breast cancer subtypes.

The main aim of my Ph.D. thesis is to further explore the value of using early developing zebrafish larvae (up to 5 dpf) as a model to study anxiety-like behaviour and their pharmacological modulation with drugs.

Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez

The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.

Ton van Haaften is met ingang van 1 maart benoemd tot Dean van de Honours Academy. Hij volgt Willemien den Ouden op, die sinds 1 september 2012 deze functie bekleedde.

Welke factoren (mens-dimensie en carnivoor-gerelateerd) zijn bepalend voor de menselijke tolerantie ten opzichte van grote carnivoren en voor de overlevingskansen van grote carnivoren in bossen met meervoudig gebruik?

Het is zonneklaar dat Rome verantwoordelijk is voor het vinden van een veilige haven, stelt onderzoeker Eugenio Cusumano.

Chapter 2 describes a post-synthetic methodology to introduce a fluorescent label in highly lipophilic, Pam3Cys based conjugates.

Promotie

One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.

Promotor: J. Zaanen, Co-Promotor: V. Juricic

This thesis discusses the discovery potential of Intensity Frontier experiments.

Cyclic peptides are investigated as a platform to induce different orientations between various ligands.

Promotor: Prof.dr. M. de Jong, Co-Promotor: A.J. Heijboer

How can we, together international experts, define future needs of R+D contributions for innovations in the field of risk-based management of chemicals and products in a global perspective using alternative testing strategies to minimize animal tests?

Een bachelor Security Studies doen en tegelijkertijd twee bedrijven opzetten en runnen: student Mohamed Sulaiman is altijd aan het werk. Maar dat doet hij met plezier en toewijding. Bij ondernemershub PLNT Den Haag krijgt hij hulp en doet hij inspiratie op.

Het doel van het RAISE Onderzoek is om te onderzoeken hoe veerkrachtige mensen omgaan met stress. We kijken specifiek naar hoe belangrijke biologische systemen, zoals de HPA-as en het immuunsysteem, samenwerken met de hersenen en de sociale omgeving om veerkrachtig functioneren na moeilijkheden in de…

The human body consists of hundreds, perhaps thousands of different types of cells, each with different morphologies and functions, despite having the same genome.

CONCLUSION: This study demonstrates that human macrophages can be induced to exert direct anti-tumor activity against osteosarcoma cells. Our observation that the induction of macrophage anti-tumor activity by L-MTP-PE required IFN-gamma may be of relevance for the optimization of L-MTP-PE therapy in…

This thesis describes the development of a variety of mannosylated conjugates. Antigen presenting cells bear mannoside recognizing receptors that actively transport antigen into the cell. This thesis exploits this feature for the development of improved vaccines.

Promotores: Prof.dr. S.J. Edixhoven, Prof.dr. E. Ullmo (University Paris-Sud)

Jobmotion

Jobmotion

The focus of this thesis is how stars like our Sun and planets like Jupiter, Saturn, and Earth are formed.

Even though more than 4000 extra-solar planets are known today, only a small fraction of these has been captured in an image. To better understand the planet formation mechanisms in solar-like environments we started the Young Suns Exoplanet Survey (YSES).

Membrane fusion is a vital process in living organisms and is mediated by zipper-like proteins.

Carbohydrates, or sugars, are the most diverse and most abundant biomolecules known. However, the isolation of carbohydrate samples in sufficient amounts and purity is often impractical or even impossible, so the chemical synthesis of glycosides becomes relevant. The glycosylation reaction, in which…

In deep reinforcement learning, searching and learning techniques are two important components. They can be used independently and in combination to deal with different problems in AI, and have achieved impressive results in game playing and robotics. These results have inspired research into artificial…

This thesis deals with the use of sound in interactions in the context of participatory systems and data sonification. We investigate an interactive environment where participants perceive information of the data through sound elements.

Where and how are critical materials currently used and how can this information be used to develop scenarios about their future demand.

One of the key discoveries in exoplanet research over the past decade is the abundance of small planets in our Milky Way. Despite their high numbers, our understanding of their atmospheres remains limited, and it is unknown if they possess atmospheres at all.

The Institute of Environmental Sciences has carried out and participates in several projects that deal with the analysis of energy systems.

Promotor: A. Kros

In condensed matter systems electron-electron interactions, negligible in everyday metals, can dramatically alter the electronic behavior of the system. Examples of such altered behavior include high-temperature superconductivity and modulation of the electron density.

My work focuses on a class of astronomical objects called protoplanetary disks.

Like a mixture of oil and water, lipid membranes separate into two liquid phases.

Metal complexes and 2D materials like graphene were combined to produce structures that can function as sensors.

Promotor: Prof.dr. M.L. van Hecke

Although nanoparticles are extensively used in various applications like consumer products and have most probably entered the environment, little is known about the effects of these particles on living organisms.

Over the past years it has been discovered that the population of extra-solar planets is large and diverse.

Animal diet studies are critical for understanding ecological processes such as trophic interactions, energy flow, and nutrient cycling. By examining what animals consume, ecologists gain insights into species specialization, predator-prey relationships, and ecosystem management.

A remarkable population of short period transiting rocky exoplanets with equilibrium temperatures on the order of 2,000 K has recently been discovered.

In the first part, we introduce a new condition, called toric-additivity, on a family of abelian varieties degenerating to a semi-abelian scheme over a normal crossing divisor.

Combinatorial games are games for two competing players, moving in a turn-by-turn fashion, in which there is no chance nor hidden information⁠. Chess, checkers and the simpler tic tac toe are well-known examples of this class of games, as well as game of go⁠.