6,066 zoekresultaten voor “leiden institute for brain and cognition” in de Publieke website
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Vaccination and Targeted Therapy Using Liposomes; Opportunities for Treatment of Atherosclerosis and Cancer
This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.
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Design, synthesis and application of sulfur-containing heterocycles for the inhibition of glycosidases and glycosyltransferases
This thesis describes the design and synthesis of novel small molecules based on sulfur-containing heterocycles for the inhibition of glycosidases and glycosyltransferases related to Fabry and Pompe disease.
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Discovery and development of inhibitors selective for human constitutive proteasome and immunoproteasome active sites
This thesis describes the design and development of subunit‐selective inhibitors of particular catalytically active subunits of human constitutive proteasomes and immunoproteasomes.
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Molecular and Nano-Engineering with Iron, Ruthenium and Carbon: Hybrid structures for Sensing
Metal complexes and 2D materials like graphene were combined to produce structures that can function as sensors.
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Methods and Tools for Mining Multivariate Time Series
Mining time series is a machine learning subfield that focuses on a particular data structure, where variables are measured over (short or long) periods of time.
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Interaction with sound for participatory systems and data sonification
This thesis deals with the use of sound in interactions in the context of participatory systems and data sonification. We investigate an interactive environment where participants perceive information of the data through sound elements.
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High-throughput quantification and unambiguous identification for metabolomics
The challenge of achieving fast quantification in metabolomics is the presence of severe matrix effects during the MS analysis of complex samples.
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Development of a low cost technology for in-situ treatment of groundwater for potable and irrigation purposes (TiPOT)
Description of Development of a low cost technology for in-situ treatment of groundwater for potable and irrigation purposes (TiPOT) (2004 - 2007)
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BRAIN wijst Leiden Universiteit aan als partner voor ontwikkeling schimmelstam
BRAIN Biotech en het Instituut Biologie Leiden (IBL) van Leiden Universiteit gaan samen een Aspergillus schimmelstam verder ontwikkelen. Deze zal in staat zijn meer te produceren en daarmee een biologische circulaire economie stimuleren. De samenwerking is gebaseerd op BRAINs moleculaire hulpmiddel…
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Lipid signaling and inflammation: metabolomics for better diagnosis and treatment strategy
Lipid signaling is an essential biological event/process in a plethora of pathophysiological conditions. The underlying idea of this thesis is that many of the roles and the complex interplay of the individual signaling lipids in inflammatory processes and related conditions in health and disease is…
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Novel detectors and algorithms for electron nano-crystallography
Promotor: Prof.dr. J.P. Abrahams, Prof.dr. M. van Heel
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Stochastic and Deterministic Algorithms for Continuous Black-Box Optimization
Continuous optimization is never easy: the exact solution is always a luxury demand and the theory of it is not always analytical and elegant.
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Onderwijs
Het Brain and Education Lab-team verzorgt verschillende vakken in het veld van Mind, Brain, and Education.
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Non-take-up of social support and the implications for social policies
This dissertation takes an important step in understanding the phenomenon of non-take-up of social support and what it means for contemporary social policies.
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Verschillen in dementie onderscheiden met hersenscans
Met geavanceerde beeldtechnieken weet neurowetenschapper Anne Hafkemeijer twee vormen van dementie van elkaar te onderscheiden. Hafkemeijer zet daarmee een eerste stap naar vroege herkenning bij de dementiepatiënt op basis van hersennetwerken. Promotie op 26 mei.
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Reliable and Fair Machine Learning for Risk Assessment
The focus of this thesis is on the technical methods which help promote the movement towards Trustworthy AI, specifically within the Inspectorate of the Netherlands.
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Statistical physics and information theory for systems with local constraints
Systems with local constraints is a new finding in recent researches on complex systems. The heterogeneous spatial interactions and the temporal dependencies among those numerous units make it difficult to describe by traditional statistical physics.
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A renewed awareness: Reinvigoratingpreparedness research for crisis and disastermanagement
IIn dit artikel blazen Jeroen Wolbers en Sanneke Kuipers het academische debat over rampenparaatheid nieuw leven in.
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Exploring Images With Deep Learning for Classification, Retrieval and Synthesis
In 2018, the number of mobile phone users will reach about 4.9 billion. Assuming an average of 5 photos taken per day using the built-in cameras would result in about 9 trillion photos annually.
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Inverse Jacobian and related topics for certain superelliptic curves
To an algebraic curve C over the complex numbers one can associate a non-negative integer g, the genus, as a measure of its complexity.
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Hoe het brein zwangere vrouwen klaarstoomt voor het moederschap
Zwangerschap veroorzaakt sterke veranderingen in hersenfuncties en die veranderingen beïnvloeden de band tussen moeder en kind. Dat ontdekten onderzoekers van Amsterdam UMC en de Universiteit Leiden. Met hun onderzoek, gepubliceerd in Nature Communications, schijnen ze licht op dit lang onontgonnen…
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SAFE and SOUND: Towards Evidence-based Policies for Safe and Sound Robots
SAFEandSOUND heeft de ambitie om de beleidscyclus te verbinden met gegevens die zijn gegenereerd in robottestzones om empirisch onderbouwde beleidsvorming voor robottechnologieën te ondersteunen.
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Imaging polarimetry for the characterisation of exoplanets and protoplanetary discs. Scientific and technical challenges
Promotor: Prof.dr. C.U. Keller
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Heterogenized molecular (pre)catalysts for water oxidation and oxygen reduction
Before the large scale use of renewable energy sources can be implemented in our society, the storage of electrical energy needs to be tackled. Storage the energy as hydrogen via the reduction of protons is a good option.
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A novel supramolecular system for membrane fusion and biosensing
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The Duke-Leiden Institute in Global and Transnational Law: Call for Applications 2019
The Grotius Centre, in collaboration with Duke Law School, will be hosting the Duke-Leiden Institute in Global and Transnational Law from 16 June to 17 July 2019 in The Hague, the International City of Peace and Justice. Applications for the second edition are now open!
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Leiden Governance Programme
Om ervaren professionals die werken op het snijvlak van publiek en privaat optimaal uit te rusten voor deze cruciale uitdagingen lanceert het Instituut Bestuurskunde van de Universiteit Leiden in 2023 het Leiden Governance Programme for Executives.
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systematic literature review of security and privacy by design principles, norms, and strategies for digital technologies
Dit artikel biedt een systematisch literatuuronderzoek van de belangrijkste principes, normen en strategieën van Security by Design en Privacy by Design.
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Duke-Leiden Institute in Global and Transnational Law 2020: Call for Applications
The Grotius Centre, in collaboration with Duke Law School, will be hosting the Duke-Leiden Institute in Global and Transnational Law from 14 June to 15 July 2020 in The Hague, the International City of Peace and Justice.
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Leiden University Centre for Linguistics
Wereldwijd zijn er ruim 7000 talen; meer dan de helft van de wereldbevolking is meertalig. Maar hoe gebruiken al die mensen hun taal? En op welke vlakken verschillende deze taken van elkaar? Onder het motto ‘Interconnecting linguistic diversity’ zijn de onderzoekers van het Leiden University Centre…
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Onderwijs
De sectie Cognitieve Psychologie draagt bij aan de 3-jarige bacheloropleiding en verzorgt 2 masterspecialisaties.
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Fertility and fontanels: women’s knowledge of medicinal plants for reproductive health and childcare in western Africa
Promotor: E.F. Smets, Co-promotor: T.R. van Andel
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800 mensen kijken in de wereld van het sociale brein
‘Of we nog een beetje kunnen aanschuiven, dan passen we er allemaal in.’ Uit het hele land komen mensen voor een interactieve dag over het sociale brein. Zes breinwetenschappers weten wat er leeft, blijkt op 6 november j.l. tijdens het publiekssymposium van het Leiden Institute for Brain and Cognition…
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Concepts and applications for evidence-based dosing in morbidly obese patients before and after weight loss surgery
Promotor: C.A.J. Knibbe, Co-promotores: H.P.A. van Dongen, B. van Ramshorst
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Regulatory Management Policies and a Universal Model for Public Policy Making, Legislative Drafting and Managing Stocks of Legislation
Op 6 juni 2019 verdedigde Edward Donelan zijn proefschrift 'Regulatory Management Policies and a Universal Model for Public Policy Making, Legislative Drafting and Managing Stocks of Legislation'. Het promotieonderzoek is begeleid door promotor prof. W.J.M. Voermans.
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Opportunity and Problem in Context (OPiC). A framework for environmental management in developing countries
Promotor: W.T. de Groot
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Invariant manifolds and applications for functional differential equations of mixed type
Promotor: S.M. Verduyn Lunel
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Functionalized two-dimensional membranes and materials for solar-to-fuel devices: a multiscale computational approach
In the current global context, there is a pressing need to address sustainable energy supplies to safeguard our Planet and its ecosystems. The choices made by human society have a significant impact on genetic evolution and climate.
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Monitoring drought and salinity stress in agriculture by remote sensing for a sustainable future
Food security is challenged by a growing global population and by climate change. Drought and soil salinity are considered the most important ones that inhibit crop yield and distribution. Worryingly, climate change is predicted to increase not only their frequency and severity, but also their co-occurrence,…
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Design, synthesis and application of paramagnetic probes for protein structure studies
The main subject of this thesis is the design and synthesis of paramagnetic molecules for protein studies with NMR and EPR spectroscopy.
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Novel formulations and delivery strategies for inactivated polio vaccines : new routes with benefits
This thesis describes the development of improved formulations and alternative delivery strategies for polio vaccination.
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Design and development of a comprehensive data management platform for cytomics: cytomicsDB
Promotor: Prof.dr. J.N. Kok
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Peer education as an opportunity for practicing respect for sexual and gender diversity
Het centrale doel van dit proefschrift is inzicht verschaffen in hoe de implementatie van een peer educator-interventie van invloed kan zijn op de houding van leerlingen tegenover LHBT-leeftijdgenoten en op de relatie tussen deze houdingen en reflectie over burgerschap.
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angucycline biosynthetic gene cluster in Streptomyces sp. QL37 and implications for lugdunomycin production
Streptomyces bacteria are a valuable source of natural products, many of which are used in the clinic or in biotechnology.
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Strategies for braiding and ground state preparation in digital quantum hardware
With the help of quantum mechanics, digital quantum hardware may be able to tackle some of the problems that are too difficult for ordinary computers. But despite these expectations and the ongoing effort of the research community, reliable quantum computers are not yet realized in a lab setting.
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Chemical functionalization of the graphene surface for electrical and electrochemical sensing application
Advanced sensing techniques require graphene with high quality and well-controlled surface chemistry.
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Zebrafish embryos and larvae as a complementary model for behavioural research
Promotor: Prof.dr. M.K. Richardson
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Two-photon multifocal microscopy for in vivo single-molecule and single-particle imaging
In this thesis we investigated the ability of two-photon multifocal microscopy for single-molecule microscopy in live cells and organisms.
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Data-Driven Machine Learning and Optimization Pipelines for Real- World Applications
Machine Learning is becoming a more and more substantial technology for industry.
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Visual analytics for spatially-resolved omics data at single cell resolution: Methods and Applications
The deeper understanding of an organism's pathology is important for developing treatments. Over centuries of systematic research, clinical researchers have demonstrated that the more information they acquire about the cellular properties and their organisation in the tissue, the better they can understand…