Fungal food spoilage often starts with a contamination with spores. Experimental data strongly indicate the existence of subpopulations of spores with different levels of resistance to preservation methods.

Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.

Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.

Promotor: A.P. IJzerman

The plant hormone auxin plays a central role in the growth and development of plants. Auxin acts in a concentration dependent manner and polar cell-to-cell transport of this hormone determines its distribution in the tissues of plants. This polar auxin transport is mediated by several families of auxin…

My PhD project studies how the temporally sequential Hox gene expression is regulated during head-tail patterning of the frog embryo.

Lezing

M.T.M. Koper, Co-promotor: D.G.H. Hetterscheid

In vitro disease models play a fundamental role in drug research. They enable the systemic identification and validation of disease mechanisms and the discovery of possible drug targets. However, more than often, drug candidates that are identified in vitro fail in the later clinical stages of drug…

Multicellular giant algae Chara species have been widely used in physiological studies for decades.

How were the Russians, under early modern conditions, able to incorporate this distant, undeveloped and, because frequent nomadic attacks, dangerous territory? And what role did the Kolyvan-Voskresensk plants play in this process?

Publicaties Onderwijs- en organisatieontwikkeling

The main aim of this project is to reveal and unravel the invisible histories of the UN, transcending the dominant Western perspective to recover the historical agency of Global South actors. The research will investigate how the UN has both facilitated and limited their role in shaping global order…

De YAL laat zich horen over beleidskwesties.

The NWO-funded Vidi project “American foreign policy and liberalism” challenges the idea that the United States has created and sustained a “liberal international order” since World War II. It instead explores the ways in which illiberal ideologies – such as those underpinning racial hierarchy at home…

Safety First. How local processes of securitization have affected the position and role of Dutch mayors. Nederlandse burgemeesters super-netwerkers. Nederlandse burgemeesters zien zich anno 2014 geconfronteerd met een grote variëteit aan nieuwe veiligheidsvraagstukken, waaronder radicalisering, loverboys…

The Sundanese people, the largest ethnic group in West Java, have been using traditional medicine for a long time. Known as ubar kampung, Sundanese indigenous knowledge, beliefs and practices of traditional medicine are based on local people’s knowledge and use of Medicinal, Aromatic, and Cosmetic (MAC)…

Did the Jochids leave their mark on the Grand Duchy, taking into account that the Lithuanian state was one of the main successor states of the Great Horde in the 16thCentury?

Promotores: Prof.dr. J. Schaye & Prof.dr. C. Steidel (California Institute of Technology)

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

This thesis focuses on amyloid proteins, a class of proteins that convert into amyloid fibrils.

Promotores:Th.J.C. van Berkel, M. van Eck

Evolution acts via mutations in amino acid sequences. Substitution of essential amino acids leads to a nonfunctional protein. l.

Onderwijs voor nieuwsgierige en ambitieuze studenten die meer uit hun studie willen halen!

Current therapies for patients with atherosclerosis are targeted primarily on reducing blood cholesterol, but this fails to prevent a large number of cardiovascular events.95 In order to identify new therapeutic strategies for treating atherosclerosis, it is important to study the interactions between…

Promotor: A.P.IJzerman, Co-Promotor: L.H. Heitman

Promotor: A.P.IJzerman Co-promotor: A. Bender

Promotor: Erik F. Smets, Co-promotores: Barbara Gravendeel, Niels Raes

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

Cardiovascular diseases are still a major concern for the global health.

Promotor: Prof.dr. E.F. van Dishoeck, Co-Promotor: G.J. Herczeg

In this research project, we aimed to obtain more insight in the role of mast cells in the immune driven disorders rheumatoid arthritis and atherosclerosis.

Promotie

Andere COI-publicaties zijn te vinden op Leiden Law Blog, de Leiden Law Methods Portal en in het drop-down-menu hieronder.

Participants in this course will learn to support student teachers and new colleagues in their professional development as teachers, with particular emphasis on the context of bilingual or international education, as in the ICLON World Teachers Programme (WTP).

Hoe kunnen we scholen helpen stress en angst in de klas te herkennen en te voorkomen en samen met scholen leerlingen snel de juiste ondersteuning bieden? Op weg naar een structurele samenwerking tussen Leidse scholen en LUBEC Kenniscentrum Angst en Stress bij jeugd.

Do e-waste workers display enhanced effects of adverse health effects due to informal e-waste processing in Nigeria? Is there a difference between the health outcomes of the exposed and the control groups? Are there difference in health effects within and between job groups (collectors, dismantlers,…

Een lijst met wetenschappelijke publicaties samengesteld door het team van het TRIXY Expertisecentrum.

How to bring together different footprints into an integrated family and what are the synergies? What are the roles of inventory analysis and characterization in measuring individual footprints and how these affect a footprint family? How to benchmark environmental footprints against related planetary…

Because thin systems can deform along the thickness with relative ease, the interplay between surface mechanics and geometry plays a fundamental role in sculpting their three-dimensional shape.

Promotor: Prof. dr. Arnold Tukker & Prof. dr. René Kemp (Maastricht University)

Curved single crystals provide variable, but well-defined surface structures.

The human body consists of hundreds, perhaps thousands of different types of cells, each with different morphologies and functions, despite having the same genome.

Promotor: A. Kros

In this thesis, deep learning is studied from a statistical perspective. Convergence rates for the worst case risk bounds of neural network estimators are obtained in the classification, density estimation and linear regression model.

Promotor: G.A. van der Marel, Co-promotor: D.C. Codée

Promotor: J. Schaye

Bacteria have the ability to alter their morphology in order to adapt to changing environments.

Light-Harvesting Complex II (LHCII) is responsible for light absorption and excitation energy transfer in plants and photosynthetic algae, while in high light it undergoes conformational changes by which it quenches excitations to prevent photodamage.