992 zoekresultaten voor “parkinson s disease” in de Publieke website
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miniaturised assays for structure-resolved lipidomics in metabolic disease
Promotie
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pharmacology of antimicrobials, towards optimized treatment of infectious diseases in hospitalized patients
Promotie
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Therapeutic neovascularization for peripheral arterial disease; in vivo models and potential therapeutic factors
Promotie
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fear of falling in middle and end stage patients with Huntington’s disease
Promotie
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Lezingen
Tijdens de Leiden Science Family Day worden er vijf lezingen gegeven: twee kinderlezingen en drie lezingen voor volwassenen. Ben jij er bij?
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Remodeling, Myocardial Function and Risk Stratification in Cardiovascular Disease
Promotie
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autoantibody-positive and autoantibody- negative rheumatoid arthritis during the disease course
Promotie
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microbiota transplantation and dietary interventions in Inflammatory Bowel Disease; efficacy and challenges for the future
Promotie
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A joint evaluation of local and systemic disease activity in treated-to- target rheumatoid arthritis
Promotie
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Unraveling the broad NOTCH3-associated small vessel disease spectrum: from CADASIL to non-penetrance
Promotie
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Non-invasive biomarkers for inflammatory skin diseases: towards systems dermatology
Promotie
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Multimodality Imaging in Coronary Artery Disease: Plaque Characterization, Computational Haemodynamic Simulation and Risk Stratification
Promotie
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Instituut Biologie Leiden
De natuur is een onuitputtelijke inspiratiebron voor de wetenschappers van het Instituut Biologie Leiden (IBL). Vanuit het streven naar fundamenteel begrip van de natuur zoeken zij naar oplossingen op het gebied van gezondheid en behoud van de biodiversiteit. Het thema van het instituut is ‘Harnessing…
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Beoordeling van troostend gedrag door twaalf maanden oude baby's: een keuze-experiment
Als mensen hebben we de neiging om bepaalde handelingen als goed of fout te beoordelen. Waar komt ons morele besef vandaan? We hebben bewijs gevonden dat baby's van slechts één jaar oud de voorkeur geven aan degenen die troosten in plaats van negeren wanneer iemand verdrietig is.
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The innate immune response against mycobacterial infection: analysis by a combination of light and electron microscopy
Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn Co-promotor: Dr. M.J.M. Schaaf
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Quantitative pharmacological modelling for optimizing treatment of sepsis
Sepsis is a life-threatening condition caused by a dysregulated host response to infection, it is associated with significant morbidity, mortality, and with a high financial burden on global healthcare systems. Bacterial infections are the primary cause of sepsis, but the growing prevalence of antimicrobial…
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Functional analysis of agrobacterium tumefaciens virulence protein VirD5
Supervisor: P.J.J. Hooykaas
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PI3K signaling and adherens junctions in invasive lobular breast cancer
Invasive lobular carcinoma (ILC) is the second most common type of breast cancer.
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Pharmaceutical Aspects of Subvisible Particles in Protein Formulations
Promotor: W. Jiskoot, Co-promotor: A. Hawe
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Discovery of novel inhibitors to investigate diacylglycerol lipases and α/β hydrolase domain 16A
Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt
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The road to insurmountability: Novel avenues to better target CC Chemokine receptors
This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.
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1,2-cis-glycosylations: method development and synthesis of complex oligosaccharides
Promotor: G.A. van der Marel, Co-promotor: D.C. Codée
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Image analysis for gene expression based phenotype characterization in yeast cells
Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek
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Phenotypic screening with 3D cell-based assays
Traditional drug discovery approaches have been hampered by (in vitro) cell-culture models that poorly represent the situation in the human body.
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Exploitation of host chemokine signalling by pathogenic mycobacteria
Promotores: A.H. Meijer, H.P. Spaink
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Modulation of leukocyte homeostasis in atherosclerosis
Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel
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Chemical Tools to Illuminate N-acylphosphatidylethanolamine Biosynthesis
This thesis describes the development and optimization of the first molecular tools to study the enzyme PLA2G4E.
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Automated de novo metabolite identification with mass spectrometry and cheminformatics
Promotor: T. Hankemeier, Co-Promotores: T. Reijmers, L. Coulier
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Chemical tools to monitor and control proteasome activities
Promotores: H.S. Overkleeft; G.A. van der Marel Co-Promotor: B.I. Florea
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Glucocerebrosidase and glycolipids: In and beyond the lysosome
The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.
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Pulling the strings on anti-cancer immunity
Promotores: J. Jonkers, K.E. de Visser
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Analysis of sub-visible particles in complex injectable formulations
Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik
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The impact of climate variability on the ecology of a lion (Panthera leo Linnaeus 1758) population and lion livestock conflicts in the Amboseli
Promotor: Prof.dr. G.R. de Snoo, Prof.dr. G.A. Persoon, Co-promotor: H.H. de Iongh
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Forces and symmetries in cells and tissues
The way organisms develop from the initial single-cellular state to a complex final assembly like the human body, and how the final body is maintained throughout life, is one of the greatest mysteries and it’s understanding one of the biggest scientific challenges.
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LUMC-hoogleraar krijgt prijs op Zeldzame Ziektendag
Prof. Judith Bovée kreeg zaterdag een prijs uitgereikt op Zeldzame Ziektendag. De prijs is een blijk van waardering vanuit de gezamenlijke patiëntenverenigingen voor haar wetenschappelijk en diagnostisch werk op het gebied van zeldzame bottumoren.
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The endocannabinoid system in zebrafish larvae
In this thesis, we have studied the potential of the zebrafish larval model in studying the ECS, as a complementary model to the existing rodent models.
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The ins and outs of ligand binding to CCR2
Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman
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Regulation of autophagy-related mechanisms during bacterial infection
Autophagy is a fundamental degradative process, maintaining cellular homeostasis and functions in host defense against intracellular pathogens, including mycobacteria and Salmonella.
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Toll-like receptor signaling in the innate immune system of zebrafish larvae
Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez
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Fulltime programme
Het schema hieronder geeft het curriculum weer van het eenjarige fulltime programma van de master Health, Ageing and Society in collegejaar 2024-2025.
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Discovery of selective diacylglycerol lipase β inhibitors
Diacylglycerol lipases (DAGLα and DAGLβ) are responsible for the biosynthesis of the endocannabinoid 2-arachidonoylglycerol (2-AG) in the brain and peripheral tissues. Selective DAGLβ inhibitors have been proposed as a potential treatment for inflammatory diseases with reduced potential for central…
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Selective autophagy in host defense against mycobacterial infection
The effective treatment of tuberculosis (TB) remains a major challenge to global health.
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Bioengineering and biophysics of viral hemorrhagic fever
Viral hemorrhagic fever (VHF) is a group of acute diseases caused by highly infectious viruses including Ebola, Lassa, Dengue viruses. Its high mortality rate poses high risk to public health, however, studies on VHF have been hampered due to the non-availability of proper models and incomplete knowledge…
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Innovative sample preparation and handling strategies for automated and high-throughput metabolomics
Metabolomics has the potential to play a pivotal role in understanding disease onset and progression, and ultimately personalized treatments. One of its major challenges is its large-scale implementation, which is necessary to deal with the high variability of the metabolome. In this work we have developed…
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The LeiCNS-PK3.0 model development and applications: healthy-to-diseased CNS pharmacokinetic translation
Accurate prediction of the unbound drug concentration-time profile at the CNS target site is crucial for the assessment of the right drug concentration-effect relationship. PBPK models have supported the PK prediction of the CNS target sites and the translation of PK data between species and between…
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Komt Goed: Appraisals, Coping en Stress van LIO's
Gevoelens en gedachten over jezelf als leerkracht spelen een hele belangrijke rol in de klas. Met dit onderzoek willen we meer inzicht krijgen in die gedachten en gevoelens. We kijken in de klas naar lessensituaties, waarbij we uitzoeken welke momenten stressvol zijn voor jullie, en welke gedachten…
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Sociale oorzaken van radicalisering: Inzichten uit Europa’s grootste extremismeonderzoek
De opkomst van extremisme in Europa heeft de polarisatie vergroot. Het door de EU gefinancierde DRIVE-project, onder leiding van Tahir Abbas, hoogleraar Radicaliseringsstudies aan het Institute of Security and Global Affairs van de Universiteit Leiden, onderzoekt hoe sociale, structurele en individuele…
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Transition metal compounds with S/N-functionalized NHC ligands: structures, redox properties and electrocatalytic activity
The research described in this thesis focused on the preparation of S/N functionalized carbene ligands and their transition metal complexes, and the exploration of their application as electrocatalysts for proton reduction.
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David de Buisonjé in de media over beloningsprogramma’s van zorgverzekeraars
Hoe beïnvloeden financiële prikkels en de beloningsprogramma’s van zorgverzekeraars ons gedrag? Brengen ze daadwerkelijk een verandering teweeg? Zo ja, is dit blijvend of slechts tijdelijk? En voor welke prikkels zijn mensen het meest gevoelig? David de Buisonjé bespreekt deze vragen en meer in de 'I'm…
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Is thyroid status a common denominator of age-related disease?
Promotie