Before the large scale use of renewable energy sources can be implemented in our society, the storage of electrical energy needs to be tackled. Storage the energy as hydrogen via the reduction of protons is a good option.

Mechanical forces are known to play an important role in bacterial colonies. In this dissertation, we study the self-organization at various stages of growing bacterial colonies, and focus on the mechanical effects of cell growth.

In the last decade, the redox interconversion between metal thiolate and disulfide compounds has been extensively investigated for copper, but not for other transition metal ions.

Despite the fact that gold nanoparticles (GNPs) are one of the most studied nanoparticles, there is still a necessity for new approaches allowing for effective protective coating to enable wider use of GNPs in biomedical applications.

A large diversity of exoplanetary systems has been found, but it is still unclear what drives this diversity.

In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).

Promotores: Prof.dr. J. Zaanen, Prof.dr. K.E. Schalm

Promotor: Prof.dr. H.J.A. Rottgering

Promotor: A.H. Meijer, Co-promotor: B.E. Snaar-Jagalska

In the thesis the dynamics of strategies is studied from two perspectives.In the first part of the thesis strategies are considered to be opinions present in a community.

According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).

Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).

Promotor: P. T. de Zeeuw, Co-promotor: N. Neumayer; G. van de Ven

My PhD project studies how the temporally sequential Hox gene expression is regulated during head-tail patterning of the frog embryo.

Despite the history of studies on methanol formation from CO2, the dominant elementary reaction steps that constitute the chemical mechanism for this catalyzed process are not determined.

During embryonic growth, cells proliferate, differentiate, and collectively migrate to form different tissues at the right position and time in the body.

Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.

The research presented in this thesis makes use of small molecules (as H2 , D2 and O2 ) on well-defined single crystal surfaces (flat Pt(111), flat Cu(211) and curved Pt(111)) to elucidate the role of surface structure and degrees of freedom in the reactant in specific surface reactions.

Sterrewacht Leiden is het sterrenkundig instituut van de Faculteit der Wiskunde en Natuurwetenschappen van de Universiteit Leiden.

This PhD-thesis analyses the relationship between the parties’ choices in the CPB Netherlands Bureau for Economic Policy Analysis’ assessments of the election manifestos and coalition agreements over the period 1986-2017, and tries to explain this relationship.

The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.

Promotor: F.J. van Lunteren, E. Jorin

Professor Paul Hooykaas en Dr. Remko Offringa sleepten namens het IBL de subsidies binnen. Het onderzoek van Hooykaas gaat over het transportsysteem van de bodembacterie Agrobacterium tumefaciens en het onderzoek van Offringa over het proces van somatische embryogenese.

Splinternieuwe technieken om erfelijke informatie in kaart te brengen en er gerichte veranderingen in aan te brengen, maar ook de bruikbaarheid van big data in veredelingsonderzoek. Daaruit bestond het programma voor een delegatie van groenteveredelingsbedrijf Rijk Zwaan, die op woensdag 29 maart de…

Ook planten maken groeihormonen aan, en kennen een proces van veroudering. Het bestuderen van de genen en de mechanismen hierachter is nuttig voor gewasveredeling en landbouw, maar ook voor medisch onderzoek. Dat stelt Remko Offringa, hoogleraar Ontwikkelingsgenetica van Planten. Oratie op 16 maart.

Natte grond, of juist te droog, met veel of weinig voedingsstoffen. Door klimaatverandering zijn de verschillen groter en moeten planten zich steeds beter kunnen aanpassen om te overleven. Hoe maak je planten stressbestendiger? Daarvoor kregen Leidse onderzoekers samen met andere universiteiten een…

Kunst en vrije tijd, Kunst en vrije tijd

CERA (CErtification of RAw Materials) is a four-year project that will develop a standardized certification scheme ensuring environmental, social and economic sustainability in extraction, processing, trading and manufacturing of all mineral raw materials. It will guarantee traceability of certified…

What are the environmental trade-offs for SMEs considering moving from monoculture aquaculture practice towards IMTA? What are the environmental trade-offs comparing IMTA species with their conventional monoculture alternatives?

NASA’s telescoop SOFIA geeft een nieuw kijkje in de chemie nabij jonge sterren: de geboorteplaats van nieuwe planeten. De Leidse promovendus Andrew Barr schrijft erover in de Astrophysical Journal. Hij en zijn collega’s vonden enorme hoeveelheden water en organische moleculen in de wervelende, schijfvormige…

Religion, Philosophy, and the Pre-modern World

Description of Effects of glufosinate-ammonium on off crop vegetation.

In this project of the Center for Public Values & Ethics (CPVE) ongoing research is conducted on the history of advice to Dutch central government by so-called State committees from 1814 to 2014. State committees have been installed by Dutch central government since 1814 to provide expert advice, research…

A neurocognitive investigation of the development of social performance monitoring in youth growing up in stressful versus non-stressful environments

Van 7-9 juni 2023 organiseert Global Transformations and Governance Challenges (GTGC) haar tweede internationale conferentie in Den Haag. Deadline voor inzendingen: 15 februari 2023.

Van 8-10 juni 2022 organiseert Global Transformations and Governance Challenges (GTGC) haar eerste internationale conferentie in Den Haag. Deadline voor inzendingen: 22 april 2022.

Op 9 september 2009 viert de opleiding Life Science and Technology (LS&T) haar tienjarig bestaan.

Examining the sustainability aspects of biotechnology, especially those related to the production of ethanol from biomass.

What are the behaviours of plant traits throughout various points in the growing season in a radiative transfer model framework and how well can this knowledge be integrated through data assimilation to provide priors for robust local and global vegetation products and analysis?

Catherina Wilson is op 1 oktober 2012 aan ons Instituut begonnen met een promotieonderzoek.